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Title: Investigação fitoquímica biomonitorada da tintura 70% de Arrabidaea chica (Humb. & Bompl.) Verlot
Other Titles: Phytochemical biomonitoring 70ºGL dye of Arrabidaea chica (Humb. & Bompl.) Verlot
metadata.dc.creator: RIBEIRO, Jeane Francisca Alves
metadata.dc.contributor.advisor1: BARBOSA, Wagner Luiz Ramos
Keywords: Arrabidaea chica
Cromatografia líquida à vacuo
Cromatografia em camada delgada
Cromatografia líquida acoplada com espectômetro de massa
Cromatografia líquida acoplada com detector de arranjo diodo
Amazônia brasileira
Issue Date: 2011
Publisher: Universidade Federal do Pará
Citation: RIBEIRO, Jeane Francisca Alves. Investigação fitoquímica biomonitorada da tintura 70% de Arrabidaea chica (Humb. & Bompl.) Verlot. 2011. 77 f. Dissertação (Mestrado) - Universidade Federal do Pará, Instituto de Ciências da Saúde, Belém, 2011. Programa de Pós-Graduação em Ciências Farmacêuticas.
Abstract: The Arrabidaea chica (H & B) Verlot, popularly known as Pariri or crajirú. Scandentia is a small shrub about 2.5 m high, occurring from southern Mexico to central Brazil, is common in the Amazon, where it is used by Indians for body painting.Popularly tea leaves is indicated for inflammation, anemia, intestinal cramps, regulate menstruation, diarrhea, among others. Recent studies have shown its antioxidant activity and wound healing in vivo and in vitro, and antifungal activity against Trichophyton mentagrophytes and trypanocidal effect. This paper aims to contribute to the validation of the claim of use and to standardize the form of employment A. chica herbal medicine as a resource, since it is in RENISUS. The ethanolic and aqueous extracts of the plant were investigated for their secondary metabolites. Parameters were determined for quality control of the plant drug, through grading, drying powder loss and total ash.Besides the chromatographic profiles obtained by TLC, CLV, LC-MS and LC - DAD. The plant meets the parameters of quality control in accordance with the literature. A CCD profile obtained with the eluent Hexane / Acetone / MeOH (67,5:27,5:5) and revealed with NP / PEG revealed a band with Rf = 0.17 with yellow fluorescence characteristic of flavonoids. In the profile of HPLC - DAD chromatograms were obtained with characteristics of quinones and flavonoids as well. From these results, the work was directed to the isolation, initially with the FAE by fractionation of CLV and analysis of resulting fractions by HPLC-DAD, and as a result suggested the presence of a flavonoid apigenin derivative of the flavonol. The microbiological results corroborate some of its popular uses thus contributing to validate the form of alleged use of the plant.
Appears in Collections:Dissertações em Ciências Farmacêuticas (Mestrado) - PPGCF/ICS

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