Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/5955
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Type: Artigo de Periódico
Issue Date: Jun-2014
Authors: GOMES, Samara Tatielle Monteiro
IMBIRIBA, Luciana
RODRÍGUEZ BURBANO, Rommel Mario
SILVA, Artur Luiz da Costa da
FEITOSA, Rosimar Neris Martins
VALLINOTO, Izaura Maria Vieira Cayres
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
VALLINOTO, Antonio Carlos Rosário
Title: Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin
Citation: GOMES, Samara Tatielle Monteiro et al. Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 47, n. 3, p. 302-306, maio/jun. 2014. Disponível em: <http://www.scielo.br/pdf/rsbmt/v47n3/0037-8682-rsbmt-47-03-302.pdf>. Acesso em: 30 jul. 2014. <http://dx.doi.org/10.1590/0037-8682-0075-2014>.
Abstract: Introduction: This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods: Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results: There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions: This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases.
Keywords: Vírus da leucemia murina
Leucemia murina
Retroviridae
Infecções por retroviridae
Belém - PA
Pará - Estado
Amazônia Brasileira
Vírus xenotrópico
Retrovírus
ISSN: 0037-8682
Appears in Collections:Artigos Científicos - ICB

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