Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/6883
metadata.dc.type: Artigo de Periódico
Issue Date: Mar-2007
metadata.dc.creator: FRANCEZ, Pablo Abdon da Costa
CORVELO, Tereza Cristina de Oliveira
SILVA, Flávio Ricardo Leal da
SANTOS, Sidney Emanoel Batista dos
Title: Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon
Citation: FRANCEZ, Pablo Abdon da Costa et al. Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon. Genetics and Molecular Biology, São Paulo, v. 30, n. 2, p. 308-313, mar. 2007. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300002&lng=pt&nrm=iso>. Acesso em: 14 set. 2015. <http://dx.doi.org/10.1590/S1415-47572007000300002>.
Abstract: The Lewis blood group system involves two major antigens, Lea and Leb. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes.
Keywords: Gene FUT3
Sistema de grupo sanguíneo Lewis
Reação em cadeia da polimerase
Japoneses
Tomé-Açu - PA
Pará - Estado
Amazônia brasileira
ISSN: 1678-4685
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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