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Title: Correlação entre autoimunidade tireoidiana e o vírus da hepatite C
metadata.dc.creator: ARAGÃO, Andrea Gomes de
metadata.dc.contributor.advisor1: QUARESMA, Juarez Antônio Simões
Keywords: Doenças transmissíveis
Vírus da hepatite C
Hepatite C
Tireoidite autoimune
Saúde pública
Pará - Estado
Amazônia brasileira
Issue Date: 2012
Publisher: Universidade Federal do Pará
Citation: ARAGÃO, Andrea Gomes de. Correlação entre autoimunidade tireoidiana e o vírus da hepatite C. 2012. 67 f. Dissertação (Mestrado) - Universidade Federal do Pará, Núcleo de Medicina Tropical, Belém, 2012. Programa de Pós-Graduação em Doenças Tropicais.
Abstract: The viral hepatitis are the most important subject of public health, being caused by differents etiologic agents. Amongst these, we find the hepatitis C virus (HCV) that according to the World Health Organization (WHO) its affects about 123 millions of people world-wide, a prevalence of 2%. The main form of transmission is the exposition to infected blood. The HCV is part of Flaviviridae family, Hepacivirus genus, its possess 6 genotypes and multiples subtypes. In Brazil, the genotype 1 is observed in 70% of infected patients, followed by genotype 3 (25%) and genotype 2 (5%). Some risk factors are strongly related with the HCV transmission, amongst them: the utilization of sterilized glass syringe at home; the sharing of utensils of personal hygiene as shavers, tooth brush, pliers of manicure and cutting nails and; blood transfusion before 1993. The present study aimed to execute an epidemiologic inquiry about risk factors related with the HCV infection and determinate the anti-HCV seroprevalence in candidates of blood donation, in the State of Pará. The following risk factors were: the use of sterilized needles and syringes at home; the use of proper material of manicure and pedicure; the use of disposable blades in public environment; the accomplishment of invasive dental treatment and; the act of receiving blood transfusion before 1993. The purpose the investigate the frequency of the autoantibodies of Brazilian hepatitis C virus carriers. The target group was represented by 14 HCV patients, while 45 healthy blood donors (HI) were included as controls. The following autobodies (Ab) to thyroid peroxidase (TPO –Ab) and anti-thyroglobulin (Tg – Ab) were investigated were investigated by indirect agglutination. In relation to the TPO – Ab, the bearers of HVC were negative in and in control group 92.86% were found positive and 15.56% 84.44% negative. As the Tg-Ab was positive in HCV carriers 92.86% 88.37% in the control group and. This study found no difference in the frequency of tireoidianas disorders when compared with hepatitis C patients without specific treatment with those without hepatitis C, probably justified, by the high prevalence of DAT in population control group. The results indicate the need for a larger sample of individuals to prove the role of hepatitis C virus alone as a trigger for DAT.
Appears in Collections:Dissertações em Doenças Tropicais (Mestrado) - PPGDT/NMT

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