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Title: Clinical applications and methemoglobinemia induced by dapsone
metadata.dc.creator: OLIVEIRA, Fábio Rodrigues de
PESSÔA, Mariely Cristine Amador
ALBUQUERQUE, Rosyana de Fatima Vieira de
SCHALCHER, Taysa Ribeiro
MONTEIRO, Marta Chagas
Keywords: Dapsona
Aplicação farmacológica
Issue Date: Oct-2014
Citation: OLIVEIRA, Fábio Rodrigues de et al. Clinical applications and methemoglobinemia induced by dapsone. Journal of the Brazilian Chemical Society, São Paulo, v. 25, n. 10, p. 1770-1779, out. 2014. Disponível em: <>. Acesso em: 6 nov. 2015. <>.
Abstract: Dapsone is a synthetic sulfone that is used as an antibiotic in humans and animals to prevent and treat diseases including leprosy, tuberculosis, malaria, and Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis in acquired immune deficiency syndrome (AIDS) patients as well as in anti-inflammatory conditions, such as dermatitis herpetiformis. However, this drug is also associated with several adverse effects, including dose-related hemolysis, methemoglobinemia, psychosis, peripheral neuropathy, agranulocytosis, aplastic anemia, hypersensitivity syndrome, sulfone syndrome, and others. Of these effects, methemoglobinemia is the most common side effect of dapsone, which leads to functional anemia and cellular hypoxia with symptoms of cyanosis, headache, fatigue, tachycardia, weakness, and dizziness. Thus, this review summarizes relevant information on the structure, mechanism of action, clinical indication, and adverse reactions of dapsone.
ISSN: 0103-5053
Appears in Collections:Artigos Científicos - FARM/ICS

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