Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/7056
Title: Inibição e reversão da agregação plaquetária de eqüinos in vitro com o uso de ketoprofeno, fenilbutazona e flunixim meglumine
Other Titles: In vitro inibition and reversion of equine platelet aggregation using ketoprophen, phenylbutazone and flunixin meglumin
metadata.dc.creator: LEME, Fabiola de Oliveira Paes
WURZINGER, Laurenz
ALVES, Geraldo Eleno Silveira
BICALHO, Adriane Pimenta da Costa-Val
BARBOSA, Marcos Pinott
PAES, Paulo Ricardo de Oliveira
OLIVEIRA, Marcos Enê Chaves
Keywords: Sangue
Plaquetas
Agregação plaquetária
Agregometria
Equino
Anti-inflamatórios
Issue Date: Oct-2009
Citation: LEME, Fabiola O. Paes et al. Inibição e reversão da agregação plaquetária de eqüinos in vitro com o uso de ketoprofeno, fenilbutazona e flunixim meglumine. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 29, n. 10, p. 803-808, out. 2009. Disponível em: <http://www.scielo.br/pdf/pvb/v29n10/a05v2910.pdf>. Acesso em: 26 jan. 2016. <http://dx.doi.org/10.1590/S0100-736X2009001000005>.
Abstract: Several diseases may lead to platelet pre-activation and hypercoagulability states in horses. The activity of many drugs against platelet aggregation may, not only contribute to the evaluation of a disease but also its response to the therapy. With the aim to study in vitro prevention and reversion of platelet aggregation, the non steroidal anti-inflammatory drug (NSAID): ketoprophen, phenylbutazone and flunixin-meglumin were evaluated. The comparison demonstrated that phenylbutazone and ketoprophen prevented platelet aggregation induced by ADP better than flunixin-meglumin, in a superior manner to the monoclonal antibody Reopro, and in a better way than the membrane receptor blockers Ro-438857 and RGDS. The reversion of platelet aggregation demonstrated that even phenylbutazone or ketoprophen have a dose-dependent effect.
URI: http://repositorio.ufpa.br/jspui/handle/2011/7056
ISSN: 0100-736X
Appears in Collections:Artigos Científicos - FEQ/ITEC

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