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Type: Artigo de Periódico
Issue Date: Dec-2016
Authors: QUEIROZ, Maria Alice Freitas
GOMES, Samara Tatielle Monteiro
ALMEIDA, Núbia Caroline Costa de
SOUSA, Maria Izete Machado de
COSTA, Suzanne Roberta Cardoso Fernandes
HERMES, Renata Bezerra
LIMA, Sandra Souza
ZANINOTTO, Marcelo Martins
FOSSA, Marco Antonio Ayin 
MANESCYH, Manoel Araujo
FEITOSA, Rosimar Neris Martins
AZEVEDO, Vânia Nakauth
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
VALLINOTO, Antonio Carlos Rosário
Title: Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia
Citation: QUEIROZ, Maria Alice Freitas et al. Mannose-binding lectin 2 (Mbl2) gene polymorphisms are related to protein plasma levels, but not to heart disease and infection by Chlamydia. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 49, n. 12, e5519, 2016. Disponível em:<>. Acesso em: 12 maio 2017. Epub 12-Dez-2016. <>.
Abstract: The presence of the single nucleotide polymorphisms in exon 1 of the mannose-binding lectin 2 (MBL2) gene was evaluated in a sample of 159 patients undergoing coronary artery bypass surgery (71 patients undergoing valve replacement surgery and 300 control subjects) to investigate a possible association between polymorphisms and heart disease with Chlamydia infection. The identification of the alleles B and D was performed using real time polymerase chain reaction (PCR) and of the allele C was accomplished through PCR assays followed by digestion with the restriction enzyme. The comparative analysis of allelic and genotypic frequencies between the three groups did not reveal any significant difference, even when related to previous Chlamydia infection. Variations in the MBL plasma levels were influenced by the presence of polymorphisms, being significantly higher in the group of cardiac patients, but without representing a risk for the disease. The results showed that despite MBL2 gene polymorphisms being associated with the protein plasma levels, the polymorphisms were not enough to predict the development of heart disease, regardless of infection with both species of Chlamydia.
Keywords: Polimofismo nos genes
Lectinas de ligação a manose
Infecções por Chlamydia
metadata.dc.relation.ispartof: Brazilian Journal of Medical and Biological Research
ISSN: 1414-431X
Country: Brasil
Publisher: Universidade Federal do Pará
Institution Acronym: UFPA
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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