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Type: Artigo de Periódico
Issue Date: Jun-2016
Authors: PAIXÃO, Susana Suely Rodrigues Milhomem
FASCINELI, Maria Luiza
ROLL, Mariana Matos
LONGO, João Paulo Figueiró
AZEVEDO, Ricardo Bentes
PIECZARKA, Julio Cesar
SALGADO, Hugo Leonardo Crisóstomo
SANTOS, Alberdan Silva
GRISOLIA, Cesar Koppe
Title: The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon
Citation: PAIXAO, Susana Suely Paixão Rodrigues et al. The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon. Genetics and Molecular Biology, Ribeirão Preto, v. 39, n. 2, p. 248-256, abr./jun. 2016. Disponível em: <>. Acesso em: 07 jul. 2017. Epub 13-Maio-2016. <
Abstract: Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of this oil for humans. The aim of this work was therefore to investigate the hematotoxicity, genotoxicity and mutagenicity of andiroba oil using the comet and micronucleus assays, and to assess its antioxidant properties and lipidome as a means of addressing safety issues. For the experiments, andiroba oil was administered by gavage for 14 consecutive days in nulliparous female Swiss mice randomly distributed in four groups: negative control and three doses of oil (500, 1000 and 2000 mg/kg/day). These doses were chosen based on recommendations of the OECD guideline no. 474 (1997). GC/MS was used to investigate the free fatty acid, cholesterol and triterpene content of andiroba oil in a lipidomic analysis. No clinical or behavioral alterations were observed throughout the period of treatment, and exposure to andiroba oil at the doses and conditions used here did not result in hematotoxic, genotoxic or mutagenic effects. Tests in vitro showed that oil sample 3 from southwestern of Brazilian Amazon had a high antioxidant capacity that may protect biological systems from oxidative stress, although this activity remains to be demonstrated in vivo.
Keywords: Lipidome
Análise hematologica
metadata.dc.relation.ispartof: Genetics and Molecular Biology
ISSN: 1678-4685
Country: Brasil
Publisher: Universidade Federal do Pará
Institution Acronym: UFPA
Appears in Collections:Artigos Científicos - ICB
Artigos Científicos - ICEN

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