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Title: Intercalação do ibuprofeno em hidróxidos duplos lamelares: caracterizações físico-químicas e avaliações biológicas
Other Titles: Intercalation of ibuprofen in layered double hydroxides: physical-chemical characterization and biological evaluation
metadata.dc.creator: SOUSA, Paulo Robson Monteiro de
metadata.dc.contributor.advisor1: SILVA, Jerônimo Lameira
Keywords: Físico-Química Inorgânica
Fármacos e medicamentos
Hidróxido duplo lamelar
Hidrotalcita de Mg-Al
Processo de intercalação
Issue Date: 14-Oct-2016
Publisher: Universidade Federal do Pará
Citation: SOUSA, Paulo Robson Monteiro de. Intercalação do ibuprofeno em hidróxidos duplos lamelares: caracterizações físico-químicas e avaliações biológicas. 2016. 144 f. Tese (Doutorado) - Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais, Belém, 2016. Programa de Pós-Graduação em Química.
Abstract: Ibuprofen-intercalated layered double hydroxides (LDH-IBU) have been successfully synthesized via a co-precipitation method with a nominal [Al3+]/[Mg2+] ratio of 0.5 and a variable molar IBU/([Al3+]+[Mg2+]) ratio of 0, 0.15, 0.18, 0.24, 0.36 and 0.72. After an accurate determination of the composition, the nature of the intercalated species and the effective intercalation yield from NO3 - to IBU, it is shown that the synthesis route used allows a good control of the quantity of intercalated IBU within the LDH framework. This results in different samples with full or partial IBU intercalation in the interlayer space in exchange of nitrate anions. The analysis of the X-ray diffraction basal reflections reveals that the intercalation of IBU in the framework only increases the basal distances with no alteration of the brucite-type layers. Also, a computational study used to model the positions and shapes of the basal reflections showed that the structure of the non-fully intercalated compounds follows a random interstratification scheme. Finally three samples ranging from slightly to fully IBU-intercalated galleries were selected for preliminary in vivo assays. These tests showed a strong tendency that after 24 hours the low yield of IBUintercalated compounds are almost as efficient as the fully intercalated sample.
Appears in Collections:Teses em Química (Doutorado) - PPGQ/ICEN

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