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Type: Artigo de Periódico
Issue Date: Jun-2017
Authors: SOUZA, Ronilson Freitas de
SILVA, Geilson Alcantara da
ARRUDA, Alberto Cardoso
SILVA, Milton Nascimento da
SANTOS, Alberdan Silva
GRISÓLIA, Daniella Paternostro de Araújo
SILVA, Moisés Batista da
ARRUDA, Mara Silvia Pinheiro
Title: A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl.
Citation: SOUZA, Ronilson Freitas de et al. A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 6, p. 1132-1136, jun. 2017. Disponível em: <>. Acesso em: 18 jul. 2017. <>.
Abstract: A new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1H and 13C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis.
Keywords: Antifúngicos
Vatairea guianensis
metadata.dc.relation.ispartof: Journal of the Brazilian Chemical Society
ISSN: 1678-4790
Country: Brasil
Publisher: Universidade Federal do Pará
Institution Acronym: UFPA
Appears in Collections:Artigos Científicos - ICB
Artigos Científicos - ICEN

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