Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/9588
metadata.dc.type: Artigo de Periódico
Issue Date: Oct-2014
metadata.dc.creator: SOUZA, Ana Maria Almeida
MUNIZ, Thiago Pimentel
BRITO, Rafael Maciel
Title: Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment
Citation: SOUZA, Ana Maria Almeida; MUNIZ, Thiago Pimentel; BRITO, Rafael Maciel. Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment. Revista Brasileira de Hematologia e Hemoterapia, São José do Rio Preto, v. 36, n. 5, p. 345-350, out. 2014. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/9588>. Acesso em:
Abstract: Objective: to evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment. Methods: data were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test. Results: there was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy. Conclusions: there are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature.
Keywords: Doença de Gaucher
Esplenomegalia
Anemia
Terapia de substituição enzimática
metadata.dc.subject.cnpq: CNPQ::CIENCIAS DA SAUDE
Series/Report no.: Revista Brasileira de Hematologia e Hemoterapia
ISSN: 1516-8484
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal do Pará
metadata.dc.publisher.initials: UFPA
metadata.dc.rights: Acesso Aberto
metadata.dc.source.uri: http://www.scielo.br/pdf/rbhh/v36n5/1516-8484-rbhh-36-05-0345.pdf
metadata.dc.identifier.doi: http://dx.doi.org/10.1016/j.bjhh.2014.05.005
Appears in Collections:Artigos Científicos - FAMED/ICS

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