Programa de Pós-Graduação em Ciências do Movimento Humano - PPGCMH/ICS
URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/15816
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Navegando Programa de Pós-Graduação em Ciências do Movimento Humano - PPGCMH/ICS por Orientadores "NEVES, Laura Maria Tomazi"
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Item Acesso aberto (Open Access) Efeito do exercício físico na força muscular, massa muscular e desempenho físico em pessoas sarcopenicas com câncer: uma revisão sistemática(Universidade Federal do Pará, 2024-12-20) GUEDES, Laerte Jonatas Leray; NEVES, Laura Maria Tomazi; http://lattes.cnpq.br/4235603520707156; https://orcid.org/0000-0002-3115-2571Cancer is the leading cause of secondary sarcopenia, representing a growing problem among people diagnosed with cancer. This condition is associated with unfavorable outcomes both in relation to disease progression and to the various types of cancer treatment. Physical exercise is recommended by several guidelines for cancer patients. However, the guidelines do not present specific recommendations for sarcopenia, and few systematic reviews have explored this topic. In addition, the effect of physical exercise on improving sarcopenia (muscle strength, muscle mass and physical performance) in cancer patients is not yet fully elucidated. Objective: To verify the effect of physical exercise on muscle strength, muscle mass and physical performance in sarcopenic people with cancer. Materials and methods: The study is a systematic review, we used the acronym PICOS as the inclusion criterion, population: adult patients diagnosed with cancer and diagnosed with sarcopenia; Intervention: physical exercise alone or associated with other interventions; control: patients in usual care, without treatment or without physical exercise; outcome: muscle strength, muscle mass, and physical performance; Types of studies: randomized controlled clinical trials. The databases used were Pubmed, Excerpta Medica database (EMBASE), Cochrane (CENTRAL), Physiotherapy Evidence Database (PEDro), Latin American and Caribbean Health Literature in Health Sciences (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and SPORTDiscus. For gray literature, Clinical trials.gov, Proquest, and the Catalog of Theses and Dissertations of the Coordination for the Improvement of Higher Education Personnel were checked, with no language or time limit. The searches were conducted until October 10, 2024. The risk of bias of the included studies was assessed by the Cochrane Risk of Bias Tool 2 and the level of evidence by the Grading of Recommendations Assessment, Development and Evaluation. Qualitative (narrative) synthesis was performed in the review, presenting the effect measures extracted from the studies individually. Results: Eight randomized controlled clinical trials were included. Three studies demonstrated an effect on skeletal muscle mass index in favor of resistance exercise (MD = 0.32 kg/m2, 95% CI [0.04; 0.60), resistance and aerobic exercise on appendicular skeletal muscle mass index (MD = 2.4 kg/m2, 95% CI [4.1; 1.30]) and resistance exercise associated with protein supplementation (MD = 0.03 kg/m2, 95% CI [0.1 0.5]). There were no differences between the intervention and control groups for the variables muscle strength and physical performance. The included studies presented risk of bias with some concerns and high risk. Additionally, all outcomes received a low level of evidence in GRADE. Conclusion: Although exercise appears to be safe and three articles indicate a possible effect on muscle mass, the studies did not have sarcopenia as a primary outcome, with prevalence rates of <50% of sarcopenic individuals in 7 studies. Thus, there is still a lack of evidence on the real effect of physical exercise on sarcopenia in cancer patients.Item Acesso aberto (Open Access) Funcionalidade após hospitalização por COVID-19 não crítico: implicações à curto e médio prazo na independência funcional, atividades de vida diária, capacidade funcional e dessaturação ao exercício(Universidade Federal do Pará, 2021-11-03) CRUZ, Soany de Jesus Valente; NEVES, Laura Maria Tomazi; http://lattes.cnpq.br/4235603520707156; https://orcid.org/0000-0002-3115-2571Coronavirus 2019 disease (COVID-19) is a highly infectious disease that can lead to hospitalization. The disease can compromise the musculoskeletal, cardiopulmonary and vascular systems, which can result in impacts on mobility and functional capacity. Objective: To assess functionality after hospitalization for non-critical COVID-19: short- and medium-term implications for functional independence, activities of daily living, functional capacity and exercise desaturation. Methods: This is a cross-sectional, analytical and descriptive study. Individuals over 18 years of age, diagnosed with non-critical COVID-19, who were hospitalized for at least 24 hours and who were discharged from the hospital, in the state of Pará, were included. Functionality and activities of daily living (ADLs) were assessed. with application of electronic forms from 30 to 180 days after hospital discharge (Barthel Index and London Chest Activity of Daily Scale (LCADL) – Article 1), and assessment of functional capacity and exercise desaturation from 90 to 180 days after hospitalization (Test 6-minute walk (6MWT) – Article 2). Results: 216 individuals were recruited, 58 individuals were included in article 1 and 46 individuals in article 2. In article 1, there was a significant difference in the Barthel Index between 1 and 6 months after hospitalization (p=0.042). No significant difference was observed in the LCADL scale. Physically active people are more likely to score higher on the Barthel Index (OR 7.32, p=0.025). In article 2, individuals after 3 months of hospital discharge walked 420m in the 6MWT, with 28% presenting a >=4% drop in SpO2. After 6 months, the distance covered was 442m, with 19.05% showing desaturation. There was no difference between groups. Conclusion: Reduced functionality, dependence to perform ADLs, reduced functional capacity and exercise desaturation were observed in post-COVID-19 non-critical patients in the short and medium term after hospital discharge.