Teses em Doenças Tropicais (Doutorado) - PPGDT/NMT
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/3560
O Doutorado Acadêmico em Doenças Tropicais iniciou em 2007 e pertence ao Programa de Pós-Graduação em Doenças Tropicais do Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA).
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Navegando Teses em Doenças Tropicais (Doutorado) - PPGDT/NMT por Orientadores "SILVEIRA, Luiz Carlos de Lima"
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Item Acesso aberto (Open Access) Eletrorretinografia multifocal: desenvolvimento de método avaliativo e aplicação em pacientes com toxoplasmose ocular e investigação funcional da função retiniana em pacientes com malária, infectados pelo P. Vivax(Universidade Federal do Pará, 2014-11-03) CARVALHO, Aline Correa de; SOUZA, Givago da Silva; http://lattes.cnpq.br/5705421011644718; SILVEIRA, Luiz Carlos de Lima; http://lattes.cnpq.br/9383834641490219The current thesis was composed by two studies performed in parallel. The first purpose was the development of a reliable method to classify the electroretinographic responses and to validate this method in ocular toxoplasmosis. The second purpose was to investigate the effect of the acute use of chloroquine in the retina of vivax malaria patients, which received the standard treatment of the Ministry of Health of Brazil. The experimental tool of both studies was the multifocal electroretinogram (mfERG). In the first study the Veris system was used to test 10 healthy subjects to calculate a signal to noise ratio analysis in order to find the best values to separate normal responses from impaired retinal responses. The final results of this analysis were applied in three patients with visual loss due ocular toxoplasmosis. The results showed an optimal signal to noise ratio of 0.47 to separate waveforms with and without signal. The signal to noise ratio of 0.47, 0.44, 0.48, 0.57, 0.78, 1.21 were optimal to separate normal responses from progressively attenuated responses. The application of the signal to noise ratio analysis into ocular toxoplasmosis patients was able to map the retinal area with no activity evoked by the light. The second study was performed using mfERG to evaluate 48 vivax malaria patients which received chloroquine-based treatment. Their data were compared to 37 healthy subjects. The results showed that number of infections ranged between from 01 to 18 times. During the treatment, the mean dosage of intaken chloroquine was 5429 ± 782.3 mg. The cumulative dosage normalized to the body mass ranged from 14.58 to 545.45 mg/kg. No difference was observed in the mfERG amplitude and implicit time obtained from malaria patients and control group at any concentric rings of the visual field. There was no significant correlation between the retinal activity with the chloroquine cumulative dosage. It was concluded that the signal to noise analysis developed in this thesis can be used as a reliable method to study impaired retinal function, including the mapping of ocular toxoplasmosis consequences; and the acute use of chloroquine for malaria treatment caused no impairments to retinal activity recorded by mfERG.Item Acesso aberto (Open Access) Interferentes bio-sócio-ambientais na exposição ao mercúrio em crianças ribeirinhas de diferentes regiões da Amazônia(Universidade Federal do Pará, 2011-06-27) AMORAS, Walter Wanderley; SILVEIRA, Luiz Carlos de Lima; http://lattes.cnpq.br/9383834641490219The present study examined possible bio-socio-environmental factors interfering in mercury exposure in children riverside. 103 children participated in the regions of the Tapajos and Acará Rivers and Marajó Island. The type of study was performed cross-sectional analysis. Hair samples were collected for analysis of the Hgtotal levels, blood (hemoglobin and hematocrit analysis) and faeces. Anthropometric indices were used to analyze children's growth. In the evaluation of psychomotor development test was applied modified Denver II screening. The highest average of Hgtotal levels in hair samples of children was in the Tapajós region (5.58 mg / g) and 0.65 g / g in other locations. The prevalence of Hgtotal> 10 mg / g was 25% and 7.5% in São Luiz do Tapajós and Barreiras. Daily consumption of fish by the families of the children as it relates to levels of Hgtotal p (value) was <0.05. The prevalence of breastfeeding duration in the groups of children under 12 months and greater than 6 months for locations in the Tapajos River, when Hgtotal related contents in hair of children with p (value) <0.05. The prevalence of anemia in the Tapajós region was 46.7% and when related to Hgtotal levels p (value) <0.0001. The parasitological tests indicated that 68.3% were multiinfested frequent when related Hgtotal p (value) <0.05. The profile of growth observed through the nutritional indicators status was 82.6% normal weight for age and 14.5% with very low weight and low. Psychomotor performance assessed by the Denver II screening test had changed five children as suspicions of developmental delays. It was concluded that in locations around the gold mining activities riverine children are at risk of mercury contamination. Bio-social- environmental factors interfering in exposure to mercury such as daily consumption of fish, length of breastfeeding, anemia, intestinal parasites showed significant statistical relationships with Hgtotal in the children's hair.