Artigos Científicos - FARM/ICS
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/2246
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Navegando Artigos Científicos - FARM/ICS por Autor "BARBOSA, Wagner Luiz Ramos"
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Item Acesso aberto (Open Access) Alcalóides de Aspidosperma auriculatum Standl(2003) BARBOSA, Wagner Luiz Ramos; TAVARES, Isabel Cecília de Castro; SOARES, Daniela CristinaSpecies from genus Aspidosperma show the presence of indol alkaloids. From Aspidosperma quebracho-blanco Schlecht quebracacidine was obtained1, from A. olivaceum. Schmutz and Hunziker2 isolated olivacine, among others substances. This work reports the determination of the chromatographic profile of alkaloid fractions from Aspidosperma auriculatum, by Thin Layer Chromatography and High Performance Liquid Chromatography. At the Brazilian state Pará this plant species has the vernacular name carapanaúba and is traditionally indicated to heal fever and others affections and also malaria. The plant material - stem bark - was extracted with hydrochloridric acid 5%. Three principal alkaloid fractions were extracted at pH 7, pH 8 and pH 11, which were analysed in suitable systems showing characteristic profilesItem Acesso aberto (Open Access) Análise farmacognóstica das folhas de Arrabidaea chica (Humb. & Bonpl.) B. Verlt., Bignoniaceae(2010-05) ALVES, Mauro Sérgio Marques; MENDES, Patrizia Cardoso; VIEIRA, Janaína Gell de Pontes; OZELA, Eliana Ferreira; BARBOSA, Wagner Luiz Ramos; SILVA JÚNIOR, José Otávio CarréraArrabidaea chica (Humb. & Bonpl.) B. Verlt. is a Bignoniaceae widely used in the popular medicine as anti-inflammatory and astringent agent, and for some illnesses as intestinal colic, diarrhoeas, anaemia and diseases of the skin. Its biological properties and dye biosynthesis lead the species to be used in the cosmetic industry. The use of natural products of vegetal origin implies in pharmacognostic quality control and purity assays that compose the technical specifications of the material. Therefore, the anatomical description of mature and young leaves of A. chica was carried through the use of optic microscopy on histological preparations. The leaves are hipostomatic and dorsiventral with heterogeneous mesophile. In petiole, the epidermis is unistratified, it contains trachoma and it is endowed with thin cuticle. The pharmacopoeia assays included the determination of the grain size distribution of the plant drug, the determination of humidity and the total ashes, beyond the phytochemistry approach of tincture, to establish parameters for its quality control.Item Acesso aberto (Open Access) Arrabidaea chica (HBK) Verlot: phytochemical approach, antifungal and trypanocidal activities(2008-12) BARBOSA, Wagner Luiz Ramos; PINTO, Lucianna do Nascimento; QUIGNARD, Etienne Louis Jacques; VIEIRA, José Maria dos Santos; SILVA JÚNIOR, José Otávio Carréra; ALBUQUERQUE, Sérgio deArrabidaea chica (HBK.) Verlot (Bignoniaceae) vernacular name "Pariri", is a climbing shrub, widespread from South Mexico to Guyana and central Brazil and is traditionally indicated to treat symptoms of inflammations and skin affections. Its ethanol extract was chemically investigated and tested against yeasts and dermatophytic fungi. The trypanocidal activity of the same extract was also evaluated. This work reports the isolation of three flavonoids, the total growth inhibition of Trichophyton mentagrophytes and a significant trypanocidal effect of the ethanol extract and its fractions. No relevant acute toxicity was detected even at a dose of 1000 mg/kgItem Acesso aberto (Open Access) Caracterização físico-química e análises por espectrofotometria e cromatografia de Peperomia pellucida L. (H. B. K.)(2013) SILVA, Rosali Maria Ferreira da; RIBEIRO, Jeane Francisca Alves; FREITAS, Manolo Cleiton Costa de; ARRUDA, Mara Silvia Pinheiro; NASCIMENTO, M.N.; BARBOSA, Wagner Luiz Ramos; ROLIM NETO, Pedro JoséThe aim of this study was the physical chemical characterization of the powder and the tincture, and the chromatographic and spectrophotometric analysis of the Peperomiapellucida L. (H. B. K.) dry extract. The methodology followed the Farmacopeia Brasileira IV ed., except for the chemical prospection, the chromatographic profile obtained and the spectrophotometry of the dry extract, and determination of dried residues. The chemical prospection revealed the presence of foaming saponins; reducing sugars; proteins and amino acids; phenols; tannins; flavonoids; steroids and triterpenoids; depsideos and depsidones. The best profile from TLC for flavonoidic fraction was obtained with methanol/formic acid (90:10 v/v). HPLC confirmed the presence of 3 ‘,4’,7-tri-methoxyflavone in the dry extract of the plant material. The results obtained in this work should contribute for the determination of specifications for a future monograph on Peperomia pellucida L. (H.B.K.)Item Acesso aberto (Open Access) Determination of myricetin derivatives in Chrysobalanus icaco L. (Chrysobalanaceae)(2006-09) BARBOSA, Wagner Luiz Ramos; PERES, Amiraldo; GALLORI, Sandra; VINCIERI, Franco FrancescoThe flavonoidic fraction composition of the hydroalcoholic extract of Chrysobalanus icaco L. (Chrysobalanaceae) leaves, which are largely used in the traditional medicine in Northern Brazil to control the glycaemia of diabetic patients, was characterised. Myricetin 3-O-glucuronide (miricitrin) and quercitrin, among other minor myricetin derivatives, were evidenced by HPLC/DAD and HPLC/MS analysisItem Acesso aberto (Open Access) Documentação e valorização da fitoterapia tradicional Kayapó nas aldeias A'Ukre e Pykanu - Sudeste do Pará(2003) BARBOSA, Wagner Luiz Ramos; PINTO, Lucianna do NascimentoIn the beginning of 1996 researchers from the program Poverty and Environment in Amazon visited the Kayapó villages A'Ukre and Pykanu in the southern of Pará State - Brazil These expeditions also aimed to rescue the kayapó phytotherapeutical tradition in the villages and to identify plant species with pharmaceutical potential. Six shamans were interviewed with translation three at each village. The shaman presented fiftythree different plants from, which twenty had elucidated their botanical identification on basis of photographyItem Acesso aberto (Open Access) Flavonóides de Cissus verticillata e a atividade hipoglicemiante do chá de suas folhas(2002) BARBOSA, Wagner Luiz Ramos; SANTOS, Wallace Raimundo Araujo dos; PINTO, Lucianna do Nascimento; TAVARES, Isabel Cecília de CastroCissus verticillata, a Vitaceae very used in the traditional medicine in Pará and Minas Gerais State – Brazil, was investigated in order to validate its indication for the hyperglycaemia control. The aqueous extract reduces the normal glycaemia of male white Wistar rats in about 19.5 %. The hypoglycaemic effect of this extract could be related to the flavonoids found in the preparation. Luteolin, Kaempferol and Luteolin-3'-sulphate could be isolated from the aqueous extract after acid hydrolysis. CissusItem Acesso aberto (Open Access) Sabedoria popular no uso de plantas medicinais pelos moradores do bairro do sossego no distrito de Marudá - PA(Universidade Federal do Pará, 2015) FLOR, Alessandra Simone Santos de Oliveira; BARBOSA, Wagner Luiz RamosIn the Amazon medicinal plants are a relevant resource for the treatment of several diseases, given the cultural context, access, reliability and low cost compared to industrial medicine. Inside this context, it is located the Marudá District, in the municipality of Marapanim,160 km far from Belém state of Pará, where it is common to use medicinal plants in order to treat health problems. In this sense, this work investigates the popular phytotherapy practice of herbal medicine practiced by the residents of the“Sossego” neighborhood in the District of Marudá-PA, illustrating the importance of medicinal plants for this human group in cultural, economic and environment context. For such purpose, we used a ethnopharmaceutical survey aiming to offer a prospecting tool of these plants employed as a therapeutic resource for the local population.