(2009-04) VIEIRA, José Luiz Fernandes; GOMES, Andreza de Lourdes Souza; BORGES, Larissa Maria Guimarães; GUIMARÃES, Erika Rodrigues
We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated
falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography
with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging
from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize
the absence of interracial difference in this relationship.
