Dissertações em Neurociências e Biologia Celular (Mestrado) - PPGNBC/ICB

URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/2375

O Mestrado Acadêmico pertence ao Programa de Pós-Graduação em Neurociências e Biologia Celular (PPGNBC) do Instituto de Ciências Biológicas (ICB) da Universidade Federal do Pará (UFPA).

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    Caracterização do genoma de tumores bem diferenciados da tireóide por hibridização genômica comparativa em matriz (aCGH)
    (Universidade Federal do Pará, 2014-03-31) ALMEIDA, Deise Cibele Nunes de; OLIVEIRA, Edivaldo Herculano Correa de; http://lattes.cnpq.br/0094007714707651
    More than 95% of thyroid gland malignancies are well-differentiated tumors. Preoperative diagnosis accuracy for papillary carcinomas, based on FNAC (Fine Needle Aspiration Cytology) and ultrasound screenings, has become nearly 100%. Nevertheless, when follicular neoplasm diagnosis is concerned, this reality is quite different. Using current preoperative screening tools, 60 – 80% of patients suspected to present follicular thyroid cancer, when operated turn out to suffer from benign disease. Therefore, in an effort to improve these results, genomic analysis of Copy Number Variations (CNV) that may more precisely differentiate follicular tumor from other thyroid conditions were carried out in 13 patients (3 bearing goiters, 2 hyperplasias, 4 follicular adenomas, 4 follicular carcinomas, 1 healthy individual). CNVs were tracked through aCGH method in order to detect follicular carcinoma most accurately. Results were compared with classic papillary carcinoma (4 subjects) and follicular variant (2 subjects). Samples demonstrated 725 CNVs, 703 of which belonging to patients with disease. Among these, 18 most frequent regions were selected. Patterns of amplification were more frequent in younger patients, while deletions were more frequent in the elder ones. Carcinoma patients presented very close CNV rates. Also, exclusive patterns of chromosomes 8 and 12 alterations were noticed in follicular carcinoma. Thus, it is possible to conclude that thyroid follicular carcinoma is a condition comprehending exclusive patterns of alterations, and progression of this disease is not related to follicular adenomas. Finally, regions -8p22 and 12p13.32-p12.33 were detected in 100% and 75% of samples respectively, therefore, may be deemed as possible tumoral markers.
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