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Navegando por Autor "CONDE, Simone Regina Souza da Silva"

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    Correlação dos níveis séricos e dos polimorfismos nos genes de citocinas (TNF-α, INF-γ, TGF-β1 e IL-10) com a apresentação clínica da hepatite B crônica
    (Universidade Federal do Pará, 2010) CONDE, Simone Regina Souza da Silva; VALLINOTO, Antonio Carlos Rosário; http://lattes.cnpq.br/3099765198910740
    Chronic hepatitis B has a wide spectrum of clinical manifestations resulting from various factors, such as the pattern of secretion and polymorphism in cytokine genes. This work aims to correlate the TNF-α -308G/A, INF-γ +874A/T, TGF-β1 -509C/T e IL-10 -1081A/G polymorphisms and serum levels of these cytokines with the clinical presentation of hepatitis B. It was selected 53 consecutive cases of hepatitis B divided into group A (inactive carrier= 30) and B (chronic hepatitis / cirrhosis= 23). As a control, we selected 100 individuals anti-HBc and anti-HBs positives. Serum levels of cytokines were determined by enzyme immunoassays (eBiosceince, Inc. California, San Diego, USA). The gene amplification of cytokines was carried out by PCR and histopathological analysis followed by METAVIR classification. It was identified that genotype TNF-α -308GA was more prevalent among B group than controls and that presence of A allele increased the risk for chronic disease (OR= 2,6). The serum levels of INF-γ and IL-10 were higher (p <0,001) in controls than others groups A and B and the TGF-β1 levels were lower (p < 0,01) in controls. It was noted that inflammatory activity > 2 correlated with higher levels of TNF-α and IFN-γ (p<0.01) and fibrosis > 2 with higher levels of INF-γ (p <0.01). In the studied population, lower INF-γ and IL-10 levels and higher TGF-β1 level were associated with chronic hepatitis B, and that the presence TNF-α -308 A allele increased in 2,6 the risk for chronic disease .
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    Equinococose policística na Amazônia oriental brasileira: atualização da casuística
    (Universidade Federal do Pará, 2004) SOARES, Manoel do Carmo Pereira; SILVA, Carlos Augusto Moreira; ALVES, Max Moreira; NUNES, Heloisa Marceliano; AMARAL, Ivanete do Socorro Abraçado; MÓIA, Lizomar de Jesus Maués Pereira; CONDE, Simone Regina Souza da Silva; CUNHA, Fernanda Barbosa de Almeida da; SILVA, Rosângela Rodrigues; CRESCENTE, Jose Angelo Barletta
    By means of epidemiological and clinical-laboratorial approaches was consolidated an update of polycystic echinococcosis in the Eastern Brazilian Amazon, period from 1962 to 2003, including unpublished cases and those already published. In that way, they were identified 40 cases of the disease in referred period, understanding cases coming from the States of Pará and Amapá, Brazil. The width of the ages went from 10 to 72 years and 47,5% belonged to the masculine sex. The liver was the attacked organ (82,5% of the cases). The Echinococcus vogeli (Rausch and Bernstein, 1972), comes as the main agent involved. Starting from the recognition of the importance and of the implications of the handling of the echinococcosis for the tropical area, it is believed that should happen an improvement of the diagnosis, appropriate treatment and of a better registration of the disease.
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    Infecções pelos vírus das hepatites B e C e o carcinoma hepatocelular na Amazônia oriental
    (2004) MIRANDA, Esther Castello Branco Mello; MÓIA, Lizomar de Jesus Maués Pereira; AMARAL, Ivanete do Socorro Abraçado; BARBOSA, Maria Silvia de Brito; CONDE, Simone Regina Souza da Silva; ARAÚJO, Marialva Tereza Ferreira de; CRUZ, Ermelinda do Rosário Moutinho da; DEMACHKI, Samia; BENSABATH, Gilberta; SOARES, Manoel do Carmo Pereira
    In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of' the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed.
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    Prevalência de genótipos e de mutantes pré-core A-1896 do vírus da hepatite B e suas implicações na hepatite crônica, em uma população da Amazônia oriental
    (2004) CONDE, Simone Regina Souza da Silva; MÓIA, Lizomar de Jesus Maués Pereira; BARBOSA, Maria Silvia de Brito; AMARAL, Ivanete do Socorro Abraçado; MIRANDA, Esther Castello Branco Mello; SOARES, Manoel do Carmo Pereira; BRITO, Elizabete Maria de Figueiredo; SOUZA, Olglaíze do Socorro Costa; ARAÚJO, Marialva Tereza Ferreira de; DEMACHKI, Samia; REBELLO, João Renato Pinho; MESQUITA, Michele Gomes Soares; BERTOLLINI, Denis Alberto; ISHAK, Ricardo
    Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the clinical presentation of chronic HBV infection. 51 HBsAg carriers (HBV-DNA positive) were selected and divided into three groups: A (14 asymptomatic subjects), B (20 HBeAg positive symptomatic patients) and C (17 HBeAg negative symptomatic patients). Using an automa ed DNA sequencer ABI model 377 by sequencing for determined of genotypes and precore mutation. The results showed that the genotype A was the most commonly found (81,1%, 89,5% and 93,7% in groups A, B and C, respectively) and precore mutation A-1896 was described in 11,5% (3/26) of group A subjects. Genotype A of HBV was the most prevalent (89,1%) and low occurrence of precore mutation A-1896, both not associate with the worst outcome of the chronic infection of HBV.
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    Programa de hepatopatias do Hospital da Fundação Santa Casa de Misericórdia do Pará: infra-estrutura e epidemiologia clínica em 10 anos de atendimento
    (2004) MÓIA, Lizomar de Jesus Maués Pereira; AMARAL, Ivanete do Socorro Abraçado; CONDE, Simone Regina Souza da Silva; BARBOSA, Maria Silvia de Brito; MIRANDA, Esther Castello Branco Mello; MACEDO, Zilvana Pinheiro de; ARAÚJO, Marialva Tereza Ferreira de; DEMACHKI, Samia; SOARES, Manoel do Carmo Pereira
    The Liver Diseases Program of the Hospital Santa Casa de Misericordia do Pará was create because of the need to attend patients with liver diseases of the Amazônia area, taking as priority to attend with quality, diagnosis of aetiologies, clinical following and specific treatment. This study aim to describe dates related to epidemiology, aetiologics agents and histopathologic analisys. One thousand sixthy nine patients were evaluated through medical, laboratory, endoscopic, ultrasound or computadorized tomography and histopathologic examination. Nine hundred thirty five (63,6%) patients within 1469 patients were diagnose as chronic liver disease. The average age was 50 year, 666 (71,2%) were male, and the most patients lived in Belem, state of Pará. The aetiologic agents most prevail were alcoholism (53,7%) and viral hepatitis (39,1%). Hepatic biopsy were done in 403 (43,1%) within the 935 patients and the results showed chronic hepatitis (34%) and chirrosis (34%). In sumary the chronic liver disease in the amazon region is more prevail in male than female, the alcoholism is the principal aetiologie, and the most of these cases were diagnose in the severe phase.
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    Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection
    (Universidade Federal do Pará, 2015-04) SÁ, Keyla Santos Guedes de; PIRES NETO, Orlando de Souza; SANTANA, Bárbara Brasil; GOMES, Samara Tatielle Monteiro; AMORAS, Ednelza da Silva Graça; CONDE, Simone Regina Souza da Silva; DEMACHKI, Sâmia; AZEVEDO, Vânia Nakauth; MACHADO, Luiz Fernando Almeida; FEITOSA, Rosimar Neris Martins; ISHAK, Marluísa de Oliveira Guimarães; ISHAK, Ricardo; VALLINOTO, Antonio Carlos Rosário
    Introduction: The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals. Results: No signifi cant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p<0.01), AST (p<0.05) and PT (p<0.05). In addition, genotypes TT (rs5743305; p<0.05) and GG (rs3775291; p<0.05) were associated with higher GGT levels. Conclusions: This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection.
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