Dissertações em Doenças Tropicais (Mestrado) - PPGDT/NMT
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/3559
O Mestrado Acadêmico em Doenças Tropicais iniciou em 2004 e pertence ao Programa de Pós-Graduação em Doenças Tropicais do Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA).
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Item Acesso aberto (Open Access) Forma oligossintomática da leishmaniose visceral americana: aspectos clínico e soroepidemiológico(Universidade Federal do Pará, 2003) ATHAYDE, Aidalucy do Socorro Costa de; SILVEIRA, Fernando Tobias; http://lattes.cnpq.br/8106158306299969The american visceral leishmaniasis (LVA) is a infectious disease, no contagious of chronic evolution and high mortality rate, being Brazil holder of 90% of the cases notified in the American continent. However, they still are not explained in an objective way the signs and symptoms of the subclinical infection, causing retard or confusion in the diagnosis of the disease. In this sense, the present work intended to previously accompany clinic and serologically the defined population, in order to characterize the subclinical form of LVA, and to study the prevalence and incidence of the infection. 307 individuals were accompanied, infected or not for the Leishmania chagasi , children and adults from 61 households, residents of the place Cabresto, Barcarena-Para, selected through clinical exam and the specific antibodies was detected by immunofluorescence reaction, between january 2000 and january 2001. For the calculation of the incidence of the infection and clinical determinant were excluded of the sample 06 patients that had already developed the classic form of the disease, in previous period. The statistical analysis was accomplished with aid of aid of the program EPINFO 0.04 and BioEstat 2.0, and the applied tests were the Quisquare, Exact Test of Fisher and G Test. In the moment of the first exam (serologically selection), 34 (11%) patients had positive serologically for the infection, however 06 of those patient ones, they had already developed the classic manifestations of LVA, elapsed the 12 months of the research appeared more 09 individuals with positive serologically of larger titles or same to ]/320, making an full of 43 (14%) infected patients by the parasite. Among the infected patients: the age groups of larger concentration were the one of young individuals, up to 24 years of age (44%); the sex of larger predominance was the male with 28 (65,1%); the signs and obvious symptoms or noticed by the subclinical individuals (5,5%), they were: paleness cutaneous-mucous membrane, lymphadenopathy, heart alteration, hepatomegaly, abdominal larging and cough. The tax of incidence of the infection was of 2,9%. None of the infected patients presented exacerbation of the symptoms or similarity manifested with the sharp form of the disease, during the twelve months of study, same when they presented higher titles of the serologically compatible with to those of patients in the classic way of LVA.Item Acesso aberto (Open Access) Prevalência de HTLV-1 e HTLV-2 em portadores de Strongyloides stercoralis, Pará, Brasil(Universidade Federal do Pará, 2012-03-12) AGUIAR, Samantha Assis de; SOUSA, Maísa Silva de; http://lattes.cnpq.br/1775363180781218; BATISTA, Evander de Jesus Oliveira; http://lattes.cnpq.br/2206444845201080The Strongyloides stercoralis is an intestinal nematode of humans that causes strongyloidiasis, a disease with worldwide distribution particularly common in tropical and subtropical regions. Epidemiological studies have demonstrated the existence of an association of this parasitic disease with Human T-cell Lymphotropic Virus type 1 (HTLV-1). In regions where both agents are endemic, the coinfection may result in the development of severe strongyloidiasis, because HTLV-1 causes a reduction in the production of immune components participating in the defense mechanisms against S. stercoralis. Based on this question, this study wanted to help and clarify the role of immunosuppression induced by HTLV-1 and HTLV-2 in the persistence and dissemination of Strongyloides stercoralis. Serological and molecular tests were used to assess the frequency of HTLV-1 and HTLV-2 in patients with S. stercoralis treated at University Hospital João de Barros Barreto, Belém Pará, in the period July 2009 to June 2011. In this study, we observed the frequency (5.50%) of anti-HTLV-1 and HTLV-2 in patients with Stongyloides stercoralis. The prevalence of HTLV-1 (3.67%) was higher than that of HTLV-2 (0.92%). The analysis of the sample showed no statistically significant differences in the frequency of HTLV-1 and HTLV-2 among men and women. At the distribution of patients with HTLV-1 and HTLV-2 by age group, we observed a higher frequency of the virus among patients with older age. Based on the results in this study, we conclude that there is need for prophylactic measures to prevent the spread of HTLV-1 and HTLV-2 among carriers of S. stercoralis and consequently prevent the development of complications resulting from the combination of these agents.