Dissertações em Neurociências e Biologia Celular (Mestrado) - PPGNBC/ICB

URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/2375

O Mestrado Acadêmico pertence ao Programa de Pós-Graduação em Neurociências e Biologia Celular (PPGNBC) do Instituto de Ciências Biológicas (ICB) da Universidade Federal do Pará (UFPA).

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    Investigação do efeito ictiotóxico do extrato etanólico da raíz de Spilanthes acmella (jambú) em zebrafish através da análise eletrofisiológica e comportamental
    (Universidade Federal do Pará, 2013-12-09) RIBEIRO, Layza Costa; ROCHA, Fernando Allan de Farias; http://lattes.cnpq.br/3882851981484245
    Among the various species of medicinal plants, we can find the Spilanthes acmella species, popularly known as Jambu that stands out due to its numerous applications in the folk medicine field. Traditional medicine recommends the use of its leaves and flowers in the preparation of infusions to treat anemia, dyspepsia, malaria, mouth diseases (tooth pain) and throat diseases, against scurvy and also as antibiotic and anesthetic, being its main effects attributed to espilantol, which is an important representative of the substances present in these plants. Some studies have been performed using the espilantol, providing some information of the effect of this substance, as its immunomodulatory effect and because of its functional interaction with monocytes, granulocytes and killer cells. However, there are still no electrophysiological studies about its ictiotoxic action using, for example, the EEG to demonstrate its action at the central nervous system level or electromyogram to verify the occurrence of their effects in the Zebrafish muscles, evoking the need for this research. Based on this, the present study aimed to investigate the ictiotoxic action of the ethanol extract of the Spilanthes acmella root in Zebrafish by electrophysiological and behavioral analysis. The results showed that the ethanol extract of Spilanthes acmella is a potent inducer of central excitability in zebrafish, this being evidenced by changes in electrical activity patterns seen in the EEG of the animals subjected to the extract and by increasing brain activity seen in the spectrogram. The extract also caused changes, in a lesser extent, on the electromyographic tracings of zebrafish subjected to the same concentration of the extract, with the appearance of scattered muscle contractions and brief myoclonus. And the behavioral findings from the delimitation of three stages of behavior, which began with the increased excitability of the animal and resulted in the seizure and death of the fish, served to corroborate the electrophysiological findings that the ethanol extract of Spilanthesacmella acts as a potent substance acting on the nervous system of zebrafish, with convulsant activity.
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