Dissertações em Neurociências e Biologia Celular (Mestrado) - PPGNBC/ICB

URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/2375

O Mestrado Acadêmico pertence ao Programa de Pós-Graduação em Neurociências e Biologia Celular (PPGNBC) do Instituto de Ciências Biológicas (ICB) da Universidade Federal do Pará (UFPA).

Navegar

Agora exibindo 1 - 2 de 2

Acesso aberto (Open Access)
Avaliar a influência do tratamento crônico com vitamina C em um modelo de estresse provocado pela dor inflamatória induzida por ácido acético em ratos wistar adolescentes
(Universidade Federal do Pará, 2018-12-21) NASCIMENTO, Gisely da Silva; BASTOS, Gilmara de Nazareth Tavares; http://lattes.cnpq.br/2487879058181806
Stress in adolescence may be linked to consequences that may persist throughout life. The injuries suffered in the brain, due to exposure to stress factors, contribute to the development of pathologies related to behavior and emotionality, such as anxiety and depression. These two pathologies have been taking on increasingly frightening proportions these days, especially among adolescents and young people, due to brain plasticity in this phase. Therefore, the aim of this study was to evaluate the influence of chronic vitamin C treatment on stress in adolescent animals in a model of inflammatory pain induced by acetic acid. Using the open field test, vitamin C was shown to significantly reduce anxiety-related behavior. This chronic treatment also satisfactorily reversed memory and learning deficits in Morris water maze. In conclusion, the chronic treatment with vitamin C has beneficial effects on the emotionality and behaviors of adolescent animals submitted to acetic acid injections. In addition, the acetic acid injection model has been shown to be efficient in inducing an anxious state of the animals.
Acesso aberto (Open Access)
Efeitos neuroprotetores e anti-inflamatórios do óleo de copaíba (Copaifera reticulata Ducke) em ratos adultos submetidos a isquemia do córtex motor por microinfecções de Edotelina-1
(Universidade Federal do Pará, 2019-02-15) SILVA, Paulo Rodrigo Oliveira da; FRANCO, Edna Cristina Santos; http://lattes.cnpq.br/5939607544965550; LEAL, Walace Gomes; http://lattes.cnpq.br/2085871005197072
Stroke is a neural disorder caused by interruption of blood flow in vessels that irrigate the brain (ischemic stroke) or rupture of these (hemorrhagic stroke), causing cognitive, sensory and / or motor deficits. With the exception of thrombolytic use, which has a very narrow therapeutic window and is little used, there are no other pharmacological treatments or cellular therapy available for this pathological condition. Thus, it is necessary to search for new treatments, such as the development of neuroprotective agents. The Amazon is a rich source of natural products, but its therapeutic actions for diseases of the central nervous system (CNS) have been little investigated. In this work, we have investigated the neuroprotective and anti-inflammatory actions of copaiba oil-resin (COR). Adult Wistar rats were submitted to focal ischemia by microinjections (80pMol/μl) of endothelin-1 (ET-1) directly into the motor cortex and were treated with daily doses of COR (400mg / kg) or 5% tween. The animals were perfused at 7 days after the injury. The histopathological analysis was performed by Nissl staining (brain) and hematoxylin-eosin (liver and kidneys). Immunohistochemistry was performed for labeling of neurons (anti-NeuN), astrocytes (anti-S100) and caspase (anti-caspase-3). Morphometry showed a reduction in the lesion size area (copaiba-treated animals (15.96 ± 1.53 mm2); control animals (28.82 ± 2.65 mm2). Histopathological examination of the liver and kidneys did not find changes indicative of toxicity. In the quantitative analysis, neuronal preservation was observed, but no statistical difference was noticed between the groups regarding astrocytes analysis (S100+ cells). The COR-treated group showed an increase in caspase-3 expression. It is concluded that COR may play a neuroprotective role, contributing to neuronal survival in the area of ischemic penumbra, but future work is needed to find out the mechanisms underlying this phenomenon.

Navegar

Navegando Dissertações em Neurociências e Biologia Celular (Mestrado) - PPGNBC/ICB por CNPq "CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA::NEUROPSICOFARMACOLOGIA"