Navegando por Linha de Pesquisa "NEUROPATOLOGIA"

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Acesso aberto (Open Access)
Análise in vitro do potencial antitumoral do conjugado LDE/Paclitaxel comparado à formulação do comercial Taxol sobre linhagem celular C6 de glioblastoma de rato
(Universidade Federal do Pará, 2022-09) ANJOS, Ana Carolina Brito dos Anjos; FRANCO, Edna Cristina Santos; http://lattes.cnpq.br/5939607544965550; https://orcid.org/0000-0003-2909-949X; LEAL, Walace Gomes; http://lattes.cnpq.br/2085871005197072
Glioblastoma, also known as grade IV astrocytoma, is one of the most common and aggressive types of tumors in the central nervous system. Among the characteristics of this type of tumor, the following stand out: infiltration of isolated tumor cells in normal brain tissue, cell proliferation, angiogenesis and intense necrosis. Currently, the main therapeutic approach consists of surgical resection followed by radiotherapy and chemotherapy. However, in most cases, the tumor is not well defined, spreading through the brain region, which makes it difficult to fully resection. In addition, the removal of tissue from this region can leave several sequels. Consequently, patients have high rates of recurrence and low rates of survival. Another problem in the treatment of this type of tumor is due to the lining of the blood-brain barrier that restricts the entry of molecules and substances, including drugs. Thus, this project aims to analyze the antineoplastic effects of the association of a nanoparticle called LDE with a structure similar to low-density lipoprotein (LDL) that will act as a carrier of the drug paclitaxel (PTX), commercially known as Taxol®, it is a chemotherapeutic drug whose cell antiproliferative action has been proven in the treatment of other types of cancer, such as breast and refractory ovarian cancers. For this purpose, the mouse glioblastoma cell line C6 was used for performing in vitro analysis regarding the effects of these treatments on aspects of viability, cytotoxicity and cell death by apoptosis, using the ApoTox-GloTM Triplex Assay kit (Promega Corporation), which performs the three previously mentioned analyses, sequentially. To evaluate growth and drug effect on PTX and LDE/PTX treatment groups, approximately 1x106 cells were cultured in 96-well microplates at concentrations of 0.01; 0.1; 1 and 10 μM in the times of 24h, 48h and 72h. The control was not exposed to the compounds, containing only DMEM culture medium. Results obtained after treatments with PTX and LDE/PTX were expressed as mean ± standard deviation and analyzed by one-way (cytotoxicity) and two-way (viability and apoptosis) ANOVA, followed by Tukey's post hoc test. Differences were considered significant when p ˂ 0.05.
Acesso aberto (Open Access)
Análise transcriptômica das linhagens celulares B103 e C6 expostas à ação do metilmercúrio
(Universidade Federal do Pará, 2023-04) BONFIM, Laís Teixeira; FERREIRA, Wallax Augusto Silva Ferreira; OLIVEIRA, Edivaldo Herculano Correa de; http://lattes.cnpq.br/009400771470765; https://orcid.org/0000-0001-6315-3352
The intensification of anthropogenic activities produces a high rate of environmental pollution, mainly in water bodies, where the contamination by metals has become an object of great interest, due to their inability to support such load. Mercury (Hg) is a naturally occurring metal that can be used in the manufacture of home products such as fluorescent lamps, fungicides, and germicides. The entry of Hg into the food chain occurs through the methylation of Hg2+ ions into MeHg. After methylation, Hg is considered highly toxic to humans, and among the main target organs of this intoxication we can mention the brain, since MeHg easily crosses the blood-brain barrier and can accumulate in different brain areas. It is known that, once in the CNS, MeHg can cause extensive cellular damage, such as DNA damage, oxidative stress, neuroinflammation and cell death in both neurons and glial cells. Thus, the objective of this study was to analyze the transcriptomic alterations of cell lines B103 and C6, derived from neuroblastoma and glioma of Rattus norvegicus, exposed to the action of methylmercury. For this, the expression microarray technique was used to evaluate the global profile of gene expression after 24h of MeHg exposure. Our results demonstrate that MeHg induces significant alterations in gene expression of the two cell lines evaluated. The alterations were more prominent in the C6 cell line, in which a greater amount of differentially expressed genes was observed. Among the genes differentially expressed of the B103 cells we can highlight the genes Cdc42se2 (log2 FC -4.055713), Dcx (log2 FC 3.618981) and 4930449C09Rik (log2 FC 3.5129156) at a concentration of 0.1 μM. As for the exposure of 2.8 μM, the genes with the highest FC were Crem (log2 FC -4.027875), Otoa (log2 FC 3.501512) and Dcx (log2 FC 3.423433). In addition to the abovementioned genes, the genes Trim14, Gm14169, Gm30871, Otoa and Dcx were shared between the two exposed groups. As for the C6 lineage, ten transcripts with FC above 3 (Aldh1l2, Dac1, Rps4l, Zbtb46, 6430573p05Rik, Tcf12, Awat2, Muc3, Dclre1b, Slc38a6) are highlighted. In the 6.3 μM treatment, only three genes were altered more than 3 times (Rps4l, Ankdr44 and 2610318N02Rik). It is also noteworthy that three genes were shared between treatments (Rps4l, Lamb 3 and Gm 41386).
Acesso aberto (Open Access)
Avaliação das alterações no sistema somatossensorial como estratégia para o diagnóstico precoce e tratamento de pacientes com transtorno do espectro autista - TEA
(Universidade Federal do Pará, 2020-01-31) SANTA MARIA, Bruna Castro; Amira Consuêlo de Melo Figueiras; http://lattes.cnpq.br/6213115471891287; BASTOS, Gilmara de Nazareth Tavares; http://lattes.cnpq.br/2487879058181806
Autism spectrum disorder (ASD) is characterized by persistent deficits in communication and social interaction in multiple contexts and restricted and repetitive patterns of behavior, interests or activities. The most recent edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), presented the addition of "hyper and hypo-reactivity to sensory input or unusual interests in sensory aspects of the environment" as defining diagnostic characteristics of autism. Individuals with autism often report tactile sensitivities, such as stiffness or withdrawal when touched. Thus, the objective of this study was to identify changes in somesthetic sensitivity that may assist in strategies for early diagnosis and intervention of patients with autism. Clinical observations and questionnaires were carried out among the participants, where it was observed that children from control group showed minimal alterations in somesthetic reactivity when compared with the ASD group. It was found that 90% of the participants in the TEA group did not play with different consistencies; 70% do not play with gelatinous objects and materials of different textures, as well as showing an aversion to certain fabrics and / or clothing labels; 62% do not participate in games that get wet or smeared and walk or walked on tiptoe and 50% avoid hugging and / or physical contact, showing that in children with autism it is possible to notice early hypo or somesthetic hyperreactivity, which could support the diagnosis and early intervention strategies.
Acesso aberto (Open Access)
Avaliação de microRNAs circulantes na esquizofrenia: da desregulação epigenômica a potenciais biomarcadores
(Universidade Federal do Pará, 2021-03) RODRIGUES, André Luiz de Souza; BURBANO, Rommel Mario Rodriguéz; http://lattes.cnpq.br/4362051219348099; https://orcid.org/0000-0002-4872-234X
Introduction: Schizophrenia is a serious and complex pathology that affects about 0.5-1% of the world's population. For the clinical diagnosis of schizophrenia, there are clinical criteria to be evaluated, which include both positive and negative symptoms. In the origin of the disease, there is a close relationship between environmental stimuli, and strong evidence shows that these stimuli have the ability to act on epigenetic mechanisms, which act in the regulation of gene expression. MicroRNAs (miRNAs) are stable and potentially reliable biomarkers, and some miRNAs have been previously identified as potential biomarkers for schizophrenia in peripheral samples. Objective: To evaluate the expression profile of circulating miRNA's in patients with schizophrenia (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) in relation to control individuals negative for the disease. Methods: Analytical, case-control, cross- sectional study using samples previously collected from patients diagnosed with Schizophrenia (N = 650) and control group (N = 924), who adequately met the inclusion criteria. The samples were analyzed after RNA extraction through its quantification and techniques for obtaining reverse transcriptase reaction and real-time quantitative polymerase chain reaction. All data were analyzed using IBM SPSS22 statistical program. Results: Using the peripheral blood collection method with the intention of finding possible biomarkers for schizophrenia, an increased expression of the miRNA’s miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652 was observed in several scenarios analyzed, confronting the case and control groups, as well as variables within the case-group, demonstrating potential diagnostic value.
Acesso aberto (Open Access)
Avaliação do óleo essencial de pau-rosa (Aniba rosaeodora Ducke) em modelo de depressão induzida por álcool em ratas adolescentes
(Universidade Federal do Pará, 2023-08) SANTOS, Éverton Renan Quaresma dos; MAIA, José Guilherme Soares; http://lattes.cnpq.br/1034534634988402; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101
Depression is a prevalent disorder worldwide, which affects the functionality and quality of life of the people. The linalool-rich rosewood essential oil (Aniba rosaeodora Ducke) displays activities on the central nervous system (CNS), including of antidepressant-type. The work aimed to evaluate the effect of the essential oil in adolescent female rats through a model of binge drinking-induced depression. The essential oil was extracted by hydrodistillation and analyzed by a dual system of gas chromatography coupled to mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (CG-FID). The in vitro antioxidant capacity of the essential oil was determined in the 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging assay. Female Wistar rats, 29 days old, received distilled water or ethanol (3 g/kg/day) orally in 4 binge episodes, and saline solution or rosewood oil (35 mg/kg) intranasally once a day for 28 days. After the experimental treatment, splash and forced swimming tests were performed. The brain-derived neurotrophic factor (BDNF) and S100B gene expression, biological parameters of the oxidative stress and levels of pro-inflammatory cytokines were determined in the prefrontal cortex and hippocampus. The OEPR+EtOH group increased self-cleaning time and decreased immobility time, both significantly compared to the EtOH group in the splash and forced swimming tests, respectively. The essential oil behavioral effects were related to positive modulation of BDNF and S100B genes, to restoration of glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC) levels, in addition to the attenuation of the increase of thiobarbituric acid reactive species (TBARS), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) induced by alcohol. The results suggest that essential oil improved the alcohol-induced depressive profile through a neuroprotective mechanism by positively modulating the gene expression of neurotrophic factors, rebalancing the antioxidant status and attenuating the inflammatory process, possibly due to the linalool action.
Acesso aberto (Open Access)
Avaliação dos níveis extracelulares de GABA e glutamato no sistema nervoso central de camundongos infectados com Plasmodium berghuei ANKA
(Universidade Federal do Pará, 2024-11) LIMA, Renato Mateus Santos de; OLIVEIRA, Karen Renata Herculano Matos; http://lattes.cnpq.br/3032008039259369
Cerebral malaria (CM) caused by Plasmodium falciparum results in high mortality, especially in children under 5, with up to 25% of survivors experiencing neurological sequelae such as cognitive impairment and seizures. The neurochemical mechanisms behind these impairments are not well understood. This study aimed to characterize changes in the levels of the neurotransmitters glutamate (GLU) and γ-Aminobutyric acid (GABA) in the central nervous system (CNS) during experimental cerebral malaria (ECM). ECM was induced in Swiss mice with Plasmodium berghei ANKA (PbA), and the animals were monitored for parasitemia, survival, and neurological impairments using the Rapid Murine Coma and Behavior Scale (RMCBS). On the 7th day post-infection (d.p.i), blood-brain barrier (BBB) disruption was assessed using Evans Blue dye, and glial cell evaluation was performed by immunofluorescence. Results showed that PbA-infected mice began to succumb to CM by the 6th d.p.i, with 100% mortality by the 10th d.p.i. Behavioral impairments were observed from the early stages of infection. Significant BBB permeability changes and increased expression of glial activation markers were noted in infected mice. There was a marked increase in GLU levels in the brain and cerebellum on days 3, 5, and 7 post-infection. GABA levels increased on days 3 and 5, returning to control levels by day 7. These findings indicate significant neurochemical alterations in GABAergic and glutamatergic neurotransmission, accompanied by neurological and vascular impairments, suggesting their involvement in the development of neurological symptoms in CM.
Acesso aberto (Open Access)
Avaliação neuropsicológica de deficits cognitivos em pessoas vivendo com HIV (PVHIV)
(Universidade Federal do Pará, 2024-08) GONÇALVES, Samilly Palheta; RODRIGUES, Anderson Raiol; ROCHA, Fernando Allan de Farias; http://lattes.cnpq.br/3882851981484245; https://orcid.org/0000-0002-6148-1050
The introduction of antiretroviral therapy resulted in a reduction in opportunistic infections associated with HIV, consequently reducing the incidence of most neurological diseases in HIV-positive patients. However, neurocognitive changes associated with HIV (HAND) remain at a significant prevalence, even in individuals using antiretroviral drugs. The present study aimed to evaluate possible cognitive deficits in HIV-positive patients and characterize the clinical profile of neurocognitive manifestations in the Northern region of Brazil. 30 HIVpositive patients were evaluated, treated at the Health Care Center for Acquired Infectious Diseases (CASA DIA), in Belém do Pará. It was possible to verify a decline in neurological functions, which affect the functional capacity of these PLHIV, with emphasis on the cognitive domain of memory and attention, where it was possible to identify through IADLs, IHDS and CANTAB.
Acesso aberto (Open Access)
Efeitos da terapia motora baseada em movimentos de dança nas funções da teoria da mente e do ritmo Mu de pessoas com doença de Parkinson
(Universidade Federal do Pará, 2023-08) VILHALVA, Jade Thalia Rodrigues; KREJCOVA, Lane Viana; http://lattes.cnpq.br/2604693973864638; BAHIA, Carlomagno Pacheco; http://lattes.cnpq.br/0910507988777644; https://orcid.org/0000-0003-3794-4710
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects brain regions whose neural circuitry is responsible for controlling voluntary movements. In addition to motor symptoms, PD patients have non-motor symptoms that drastically affect their quality of life. These include cognitive alterations, among which deficits in working memory, deficits in executive functions and in the ability to deduce the mental states of others (Theory of Mind: ToM) stand out, and may also be related to the functions of mirror neurons (MN). The MN are neurons activated when a person performs or observes a given action, thus performing “internal” simulation of the observed acts, a necessary process for the ability to recognize emotions and intentions in the ToM. Their activity is influenced by prior training of observed motor actions and can be recorded using electroencephalography (EEG) through changes in the Mu band wave amplitudes (alpha 1 waves) detected when an individual observes the actions of another person. The present work investigated the effects of motor therapy on electroencephalographic activity and its correlations with MT functions in patients affected by PD. For this purpose, electroencephalographic evaluations were performed to investigate desynchronization patterns characteristic of mirror neuron activity, in addition to the Reading the Mind in the Eyes (RME) and Faux Pas Recognition (FPR) tests. We evaluated patients diagnosed with PD (n=09), under pharmacological regimen, Hoehn and Yahr 2-4, of both sexes and with mean age of 62.9 ± 7.1 years and mean of 5.8 ± 1.3 years of diagnosis , in time windows before joining the project after twelve months of participation in 2 weekly sessions of motor therapy in dance. Tabulated data were analyzed using Student's t-test. No significant differences were observed in the evaluation parameters of the FPR test in the Test and Retest temporal windows, whereas in the RMT test the average score obtained by the participants in the Test was 9.7 points, while in the Retest the average was 11.3 points with observed significance (p=0.0148), whereas electroencephalographic statistical analysis (TRPs) showed significant results in the level of desynchronization of alpha 1 waves (p=0.014 and p=0.010) during specific electrophysiological evaluation. The data showed that although the individuals did not show improvement in performance in most components of the analyzed TM tests, the electrophysiological results indicate alteration of specific cortical activity related to the activation of the mirror neuron system, influenced by motor therapy in dance, which may configure then, as an adjuvant therapeutic option in the management of motor and non-motor symptoms of PD.
Acesso aberto (Open Access)
Efeitos neuroprotetores e anti-inflamatórios do óleo de copaíba (Copaifera reticulata Ducke) em ratos adultos submetidos a isquemia do córtex motor por microinfecções de Edotelina-1
(Universidade Federal do Pará, 2019-02-15) SILVA, Paulo Rodrigo Oliveira da; FRANCO, Edna Cristina Santos; http://lattes.cnpq.br/5939607544965550; LEAL, Walace Gomes; http://lattes.cnpq.br/2085871005197072
Stroke is a neural disorder caused by interruption of blood flow in vessels that irrigate the brain (ischemic stroke) or rupture of these (hemorrhagic stroke), causing cognitive, sensory and / or motor deficits. With the exception of thrombolytic use, which has a very narrow therapeutic window and is little used, there are no other pharmacological treatments or cellular therapy available for this pathological condition. Thus, it is necessary to search for new treatments, such as the development of neuroprotective agents. The Amazon is a rich source of natural products, but its therapeutic actions for diseases of the central nervous system (CNS) have been little investigated. In this work, we have investigated the neuroprotective and anti-inflammatory actions of copaiba oil-resin (COR). Adult Wistar rats were submitted to focal ischemia by microinjections (80pMol/μl) of endothelin-1 (ET-1) directly into the motor cortex and were treated with daily doses of COR (400mg / kg) or 5% tween. The animals were perfused at 7 days after the injury. The histopathological analysis was performed by Nissl staining (brain) and hematoxylin-eosin (liver and kidneys). Immunohistochemistry was performed for labeling of neurons (anti-NeuN), astrocytes (anti-S100) and caspase (anti-caspase-3). Morphometry showed a reduction in the lesion size area (copaiba-treated animals (15.96 ± 1.53 mm2); control animals (28.82 ± 2.65 mm2). Histopathological examination of the liver and kidneys did not find changes indicative of toxicity. In the quantitative analysis, neuronal preservation was observed, but no statistical difference was noticed between the groups regarding astrocytes analysis (S100+ cells). The COR-treated group showed an increase in caspase-3 expression. It is concluded that COR may play a neuroprotective role, contributing to neuronal survival in the area of ischemic penumbra, but future work is needed to find out the mechanisms underlying this phenomenon.
Acesso aberto (Open Access)
Melatonina previne danos cerebrais e déficits cognitivos induzidos pela infecção por Plasmodium berghei anka em modelo murino de malária cerebral
(Universidade Federal do Pará, 2021-05) ATAIDE, Brenda Jaqueline de Azevedo; OLIVEIRA, Karen Renata Herculano Matos; http://lattes.cnpq.br/3032008039259369
Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and nervous tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in the control of brain functions and maintenance of blood–brain barrier integrity. The current study has evaluated the effect of melatonin on the histological alterations, blood–brain barrier leakage, and neurocognitive impairments in mice developing cerebral malaria. Swiss mice infected with Plasmodium berghei ANKA strain was used as cerebral malaria model. Melatonin treatment (5 and 10 mg/kg) was performed for four consecutive days after the infection, and data have shown an increased survival rate in infected mice treated with melatonin. It was also observed that melatonin treatment blocked brain edema and prevented the breakdown of blood–brain barrier induced by the Plasmodium infection. Furthermore, hematoxylin and eosin staining revealed that melatonin mitigates the histological alterations in Plasmodium-infected animals. Melatonin was also able to prevent motor and cognitive impairments in infected mice. Taken together, these results show for the first time that melatonin treatment prevents histological brain damages and neurocognitive alterations induced by cerebral malaria
Acesso aberto (Open Access)
Modelo de hemiparkinsonismo por 6-hidroxidopamina em primatas Sapajus apella: características comportamentais e histológicas
(Universidade Federal do Pará, 2024-10) PEDROSA, Laís Resque Russo; KREJCOVÁ, Lane Viana; http://lattes.cnpq.br/2604693973864638; GOMES, Bruno Duarte; http://lattes.cnpq.br/4932238030330851
Despite considerable side effects and decreasing effectiveness over time, the treatment for Parkinson's disease (PD) has remained largely unchanged for over 50 years. However, several aspects of the disease's pathophysiology remain poorly understood. The development of new therapies and the elucidation of mechanisms related to the disease are among the biggest current challenges in neuroscience research. In this context, non-human primate (NHP) experimental models are particularly relevant due to their high phylogenetic proximity, encephalization rate, and complex motor and behavioral repertoire, confer high predictive power for clinical outcomes. The 6-hydroxydopamine inoculation model of parkinsonism mimics relevant features of PD and may represent an important experimental refinement in primates. The present study aimed to develop a model of hemiparkinsonism induction in Sapajus apella primates, characterizing the behavioral and histological aspects. For this purpose, adult male Sapajus apella monkeys were subjected to motor tests to observe motor performance before and after unilateral injection of 6-OHDA in the nigrostriatal pathways at concentrations of 4 (N=1), 10 (N=1) and 40 (N=1) mg/μl in the dominant hemisphere. As a surgical control (N=1), one animal underwent surgery containing only solvent. Stereotaxic coordinates for the 12 6-OHDA inoculation sites were calculated based on individual Magnetic Resonance Imaging (MRI) images. Immunohistochemistry for tyrosine hydroxylase (TH) was performed on 50 μm coronal sections of the midbrain. As a statistical analysis, two-way ANOVA was used to verify possible differences in behavioral parameters and neuronal exclusion between groups, considering the dominant (therefore affected) and non-dominant hemispheres. There were significant changes in motor patterns of dominance and manual preference after surgical intervention. 6-OHDA induction in the nigrostriatal pathways appears to be a good method of inducing parkinsonism with the induction of detectable symptoms in primates.
Acesso aberto (Open Access)
Tamanho de tumores da região selar como um preditor de perdas psicofísicas e eletrofisiológicas de campo visual
(Universidade Federal do Pará, 2019-11) LOBÃO, Carlos Augusto Ferreira; SOUZA, Givago da Silva; http://lattes.cnpq.br/5705421011644718; https://orcid.org/0000-0002-4525-3971
Sellar region tumor growth represents an important cause of visual loss due mechanical compression of the optic nerve apparatus. Many investigations have used non-invasive tools to evaluate the visual field consequences of this damage, and good association have been reported between psychophysical and electrophysiological perimetry. Few reports have considered the tumor size as predictor of the visual field loss. Objectives: In the present study, it was evaluated the association between tumor size and visual perimetry alterations measured by a psychophysical method, the Humphrey Visual Field Analyzer perimetry, and an electrophysiological method using the multifocal visual evoked cortical potential (mfVECP). Methods: The analyzed sample was composed by 14 patients diagnosed with sellar tumors on magnetic resonance imaging. The number of sectors with negative visual responses for both methods was counted. A simple logistic regression analysis was used to evaluate the association between the tumor dimensions and the visual field features. Results: Three patients had preserved visual fields, three patients showed hemianopic defects, and eight patients had generalized visual field losses at both evaluations. It was observed that the three maximum diameters of the tumor and total tumor volume had different predictive abilities regarding the extent of visual field loss when using psychophysical and mfVECP data. The maximum craniocaudal diameter of the tumor was the better predictor of the psychophysical measurements, while for mfVECP results, all tumor dimensions and volume had similar value to predict visual field losses. Conclusion: Sellar region tumor size is a predictor of visual loss found on psychophysical and electrophysiological visual perimetry. This correlation has potential to assist in the clinical intervention, and to prevent the irreversible visual impairment caused by these tumors to the patient.
Acesso aberto (Open Access)
Viabilidade e eficácia da telerreabilitação e da cartilha de exercícios para pessoas com doença de Parkinson residentes em uma região da Amazônia brasileira: um ensaio clínico randomizado
(Universidade Federal do Pará, 2023-12) RAMOS, Luciana Fernandes Pastana; YAMADA, Elizabeth Sumi; http://lattes.cnpq.br/7240314827308306; LOBATO, Bruno Lopes Santos
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder, and the current treatment involves pharmacological intervention and physiotherapy. Telerehabilitation, which involves remote support and guidance for patients undergoing rehabilitation, can potentially improve access to physiotherapy services for people with Parkinson's disease, especially those who face geographic barriers to healthcare. The primary aim of this study was to assess the feasibility and efficacy of a telerehabilitation program for people with Parkinson's disease living in an underrepresented community of the Brazilian Amazon. We conducted a parallel-group, single-center, single-blind, randomized clinical trial involving 19 participants diagnosed with Parkinson's disease from Belém, Brazil. Participants were assigned to a 4-week individual telerehabilitation program or a booklet-based exercise program (control group). Assessments were conducted before the intervention, immediately after the intervention, and 4 weeks after the end of the intervention. We showed that our telerehabilitation program had high adherence among patients, with minimal adverse effects. Both telerehabilitation and booklet orientation reduced the time to complete the Timed Up and Go test. In conclusion, our telerehabilitation or booklet-based exercise program was feasible and effective for people with Parkinson's disease in an Amazonian setting. This trial was registered at the Registro Brasileiro de Ensaios Clínicos (ReBEC) under the identifier: RBR-6sz837s.