Dissertações em Doenças Tropicais (Mestrado) - PPGDT/NMT

URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/3559

O Mestrado Acadêmico em Doenças Tropicais iniciou em 2004 e pertence ao Programa de Pós-Graduação em Doenças Tropicais do Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA).

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Acesso aberto (Open Access)
Estudo de prevalência da esquistossomose mansônica no bairro do Maracajá, distrito de Mosqueiro, Belém, Pará
(Universidade Federal do Pará, 2012) MALCHER, Sérgio Alexandre Oliveira; BICHARA, Cléa Nazaré Carneiro
Schistosomiasis mansoni is one of the most widespread parasitic diseases in the world and has a higher prevalence in developing countries, and is currently a serious public health problem in Brazil. In Belém-PA, District Administrative Mosqueiro (DAMOS), there are possibilities of occurrence of autochthonous cases of schistosomiasis mansoni, due to geographical proximity to other areas where there are records of this disease, as well as the presence of other environmental risk factors, as the presence of Biomphalaria straminea. With the proposal to determine the prevalence of schistosomiasis mansoni in the neighborhood of Marazion-DAMOS, a cross-sectional study was conducted prospectively between March 2011 and January 2012, through parasitological survey by the quantitative method of Kato- Katz, associated with social inquiry demographic and environmental location. Participated in the sampling universe included 407 individuals in the care of the Family Health Strategy, which voluntarily agreed to participate in the survey, according to the ethical regulations. The socio-demographic profile of the population was mainly aged between 11 and 40 years without gender differences, whose occupation of housewife and student, with incomplete primary education were the most cited. Most residents were born and proceeds from the DAMOS, residents in the neighborhood of Marazion for over 20 years, without reports of significant displacement to other locations. Most households had piped water service, with indoor bathroom, toilet presence of bound stools in the septic tank. Water collections peridomestic ditches were characterized by low flow and small water flow, high concentration of organic products, the presence of vegetation and macrófitica vector Biomphalaria straminea. This population reported having no contact with the water collection and know the planorbid vector, as well as the very schistosomiasis The investigation has resulted in 100% parasitological blade negative and the identification of eggs of S. mansoni, leading to the conclusion that although the neighborhood of Marazion is still harmless, several factors have to install a focus of active transmission of schistosomiasis, but there is still a fragile ecological balance, supported by the reduced exposure of individuals to water collection, bit shift population to areas with established foci of endemic and reasonable coverage of sanitation. This set of variables has acted as limiting factors to the process of endemic schistosomiasis in the neighborhood of Marazion, however, must be kept under surveillance by the peculiarities conducive to closing the cycle of S. mansoni.
Acesso aberto (Open Access)
Prevalência de HTLV-1 e HTLV-2 em portadores de Strongyloides stercoralis, Pará, Brasil
(Universidade Federal do Pará, 2012-03-12) AGUIAR, Samantha Assis de; SOUSA, Maísa Silva de; http://lattes.cnpq.br/1775363180781218; BATISTA, Evander de Jesus Oliveira; http://lattes.cnpq.br/2206444845201080
The Strongyloides stercoralis is an intestinal nematode of humans that causes strongyloidiasis, a disease with worldwide distribution particularly common in tropical and subtropical regions. Epidemiological studies have demonstrated the existence of an association of this parasitic disease with Human T-cell Lymphotropic Virus type 1 (HTLV-1). In regions where both agents are endemic, the coinfection may result in the development of severe strongyloidiasis, because HTLV-1 causes a reduction in the production of immune components participating in the defense mechanisms against S. stercoralis. Based on this question, this study wanted to help and clarify the role of immunosuppression induced by HTLV-1 and HTLV-2 in the persistence and dissemination of Strongyloides stercoralis. Serological and molecular tests were used to assess the frequency of HTLV-1 and HTLV-2 in patients with S. stercoralis treated at University Hospital João de Barros Barreto, Belém Pará, in the period July 2009 to June 2011. In this study, we observed the frequency (5.50%) of anti-HTLV-1 and HTLV-2 in patients with Stongyloides stercoralis. The prevalence of HTLV-1 (3.67%) was higher than that of HTLV-2 (0.92%). The analysis of the sample showed no statistically significant differences in the frequency of HTLV-1 and HTLV-2 among men and women. At the distribution of patients with HTLV-1 and HTLV-2 by age group, we observed a higher frequency of the virus among patients with older age. Based on the results in this study, we conclude that there is need for prophylactic measures to prevent the spread of HTLV-1 and HTLV-2 among carriers of S. stercoralis and consequently prevent the development of complications resulting from the combination of these agents.

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