Dissertações em Doenças Tropicais (Mestrado) - PPGDT/NMT
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/3559
O Mestrado Acadêmico em Doenças Tropicais iniciou em 2004 e pertence ao Programa de Pós-Graduação em Doenças Tropicais do Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA).
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Dissertação Acesso aberto (Open Access) Aplicação do modelo de acurácia em casos suspeitos de amebíase em uma comunidade rural do nordeste do Estado do Pará, Brasil(Universidade Federal do Pará, 2006) REZENDE, Manoel Antônio Costa de; ISHIKAWA, Edna Aoba Yassui; http://lattes.cnpq.br/3074963539505872Introduction: The studies on the prevalence of intestinal worms are scarce among us, most of them were performed in sample of populational basis not very well defined, like users of health service and public school students. Objective: Quantify the Entamoeba hystolitica prevalence in a rural population of Pará state. Methods: feces study using the ferric hematoxilina method in 124 people from the rural part of Tailândia, arbitrarily selected in order to establish prevalence and accuracy, the positive and negative predictive values, as well as sensitivity and specificity. Results: from the populational sample, 56,5% belonged to male sex, 60,5% out of these were ranging between 18 to 43 years old. In the scholarship study, 64,5% had at least 3 years of school and 63,7% earned less than R$300,00. The Entamoeba hystolitica prevalence reached 24,2%. Conclusion: the accuracy, which is the measurement of global value of the performed test, shows that 73,4% of the patients were correctly classified. The 70,0% sensitivity test defined positive for the infection and a specificity of 74,5%.Dissertação Acesso aberto (Open Access) Avaliação in vitro dos efeitos de miltefosina, orizalina e TC95 no crescimento de Entamoeba histolytica(Universidade Federal do Pará, 2011) ALVARENGA, Betânia Mara; BATISTA, Evander de Jesus Oliveira; http://lattes.cnpq.br/2206444845201080Amebiasis is characterized as a chronic, noninflammatory, afebrile which involves the colon wall and can invade the intestinal mucosa and spread to other organs, especially the liver. Entamoeba histolytica infection is treated with metronidazole, but this one presents side effects, so researches have been done to find more effective drugs with no adverse effects to the patient. In addition, testing new drugs may reveal important features of the parasite, such as the discovery of metabolic pathways or possible differences in their structure. In the present study, it was tested the amoebicidal effect of metronidazole, dinitroaniline oryzalin, a microtubule inhibitor, miltefosine, an alkylphosphocholine, that inhibits the membrane phospholipids syntesis, and TC95, a hybrid drug that presents the functional groups dinitroaniline and alkylphosphocholine. It was performed a culture with protozoan trophozoites, where the drugs and the control with diluents were added after 7 hours of culture. It was made a count of the viable trophozoites 12 hours after the addition of the drugs and the control at intervals of 12 to 60 hours. After analyzing the growth curves, it was found that the TC95 was the most effective drug of the three treatments, miltefosine had little inhibition and oryzalin was not effective. This is due to greater susceptibility of the parasite to membrane damage, with little effectiveness on microtubules inhibition.