Teses em Doenças Tropicais (Doutorado) - PPGDT/NMT
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/3560
O Doutorado Acadêmico em Doenças Tropicais iniciou em 2007 e pertence ao Programa de Pós-Graduação em Doenças Tropicais do Núcleo de Medicina Tropical (NMT) da Universidade Federal do Pará (UFPA).
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Item Acesso aberto (Open Access) Epidemiologia da infecção genital pelo Papilomavírus humano (HPV) em população urbana e rural da Amazônia Oriental Brasileira(Universidade Federal do Pará, 2010-04-19) PINTO, Denise da Silva; FUZII, Hellen Thais; http://lattes.cnpq.br/0026958665547973; QUARESMA, Juarez Antônio Simões; http://lattes.cnpq.br/3350166863853054The main cause of the development of precursor lesions and neoplastic processes in the uterine cervix is the genital infection by human papillomavirus (HPV). Cervical cancer is the second largest cause of cancer death among Brazilian women, It is one of the major causes of morbidity and mortality of women in north of Brazil indeed. This research aimed to investigate the epidemiology of genital infection by human papillomavirus (HPV) in women from rural and urban population from two distinct regions of the Western Brazilian Amazon. A Transversal analytic study was taken with 444 females between 13 and 74 years who were volunteers in a preventive examination for cervical cancer, 233 women from an urban primary care unit in Belem Para and 211 women from the right and left side of the Tucurui Lake in Para. It started in January 2008 until March 2010. Uterine cervix samples were collected for a conventional Pap Smears examination and for the detection the DNA of HPV by polymerase chain reaction (PCR) using the universal primers MY9/11. A hundred percent of the volunteers answered a clinical and epidemiological questionnaire. In order to better analyze the epidemiological association between the risky factors and infection by HPV. The samples were divided in three different age groups. Being derived odds ratio of prevalence (ORP) 95% of IC, with its significance verified using the qui-square of Pearson or Fisher exact test, and the final use of multivariate logistic regression model. Among the 444 volunteers, the massive prevalence of genital HPV infection was 14.6%, ranging between 15.0% for the urban sample and 14.2% for the rural ones. The most affected age group was between 13 to 25 years (17.9%), both in the urban sample (19.0%) and rural (17.2%). HPV DNA was found in 13.6% of women with normal cytology and in 41.6% of those with abnormal cytology, this result was more significant for the urban volunteers of the study aged between 26 to 44 years old. Cytological abnormalities, early onset of sexual activity, marital status, number of sex partners recent or old, a premature use of oral contraceptives and condoms, STI’s and genital symptoms, the current smoking in taken, are factors that were associated with genital infections by HPV differently in the three age groups between urban and rural samples of the western Brazilian Amazon.