Navegando por Assunto "Depression"

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Acesso aberto (Open Access)
Análise comportamental e eletrofisiológica do uso de glicocorticoides no sistema nervoso central em modelos animais de depressão
(Universidade Federal do Pará, 2017-01-31) CARDOSO, Keilla Gisele Mendonça; GOMES, Daniela Lopes; http://lattes.cnpq.br/0014255351015569; LIMA, Silene Maria Araújo de; CV: http://lattes.cnpq.br/8961057812067156
Dexamethasone is a glucocorticoid widely prescribed in Medicine, used as immunosuppressant and anti-inflammatory as well as fluoxetine, which is an antidepressant, serotonin reuptake, which can be used at some point while aiming their respective purposes. The aim of this study was to evaluate the electroencephalographic abnormalities in animals administered with these drugs as well as the behavioral effects evaluated in an animal model of depression, forced swimming. The study was conducted in adult male Wistar rats subjected to administration of dexamethasone acute dose of 4 mg/kg, 24 hours before electrocorticographic record, and chronic, administered for seven days every 24 hours at a dose of 4 mg/kg i.p. Fluoxetine was administered at a dose of 5 mg/kg, for seven days orally with a similar tool the orogastric tube, gavage procedure. After administration, the electroencephalographic parameters of drug activity were recorded and analyzed. When comparing the acute administration of dexamethasone with chronic, there were no statistical differences, but there was a trend towards decreased Theta and Gamma force for chronic use. The group, who received fluoxetine averaged amplitude of 2,661 ± 0,5850 mV²/Hz x 10-3, proving fluoxetine efficacy in controlling depression caused by forced swimming. For the group received dexamethasone chronically and fluoxetine to reverse the power of the middle frame was 0.4758 ± 0.2514 mV²/Hz x 10-3, as there is no statistical difference between the dexamethasone group and dexamethasone fluoxetine, fluoxetine failed to reverse depressive symptoms caused by dexamethasone. In the forced swimming, the fluoxetine group had decreased fluctuation time, mean time of 45.33 ± 23.26 seconds, demonstrating that the group was not depressed. In the group administered with dexamethasone chronic form and assessed the possibility of reversing depressive disorder with fluoxetine immobility time average was 169.8 ± 24.5 seconds indicating that fluoxetine had no effect on the depression caused by chronic application of dexamethasone. We conclude from this study that the glucocorticoid cause changes in electrocorticogram and depression in the forced swimming test (FST). Fluoxetine got no effect on the rats subjected to the FST, after the use of dexamethasone.
Acesso aberto (Open Access)
Depression after CABG: a prospective study
(Sociedade Brasileira de Cirurgia Cardiovascular, 2013-12) NUNES, Joana Kátya Veras Rodrigues Sampaio; FIGUEIREDO NETO, José Albuquerque de; SOUSA, Rosângela Maria Lopes de; COSTA, Vera Lívia Xavier de Castro; SILVA, Flor de Maria Araújo Mendonça; HORA, Ana Flávia Lima Teles da; SILVA, Edna Lúcia Coutinho da; REIS, Lívia Mariane Castelo Branco
INTRODUCTION: Depression during or shortly after hospitalization elevated two to three times the risk of mortality or nonfatal cardiac events, significantly increasing the morbidity and mortality of these patients. OBJECTIVE: To assess the impact of revascularization on symptoms of depression in patients with coronary artery disease. METHODS: A prospective cohort study of 57 patients of both sexes undergoing coronary artery bypass grafting between June 2010 and June 2011. We used the SF-36 to assess quality of life, and the Beck Depression Inventory to detect depressive symptoms, applied preoperatively and six months. RESULTS: The prevalence of patients aged 60-69 years was 22 patients (38.60%), 39 men (68.42%), 26 described themselves as mixed race (45.61%), 16 literate (28.07 %) and 30 married (52.63%). The beck depression inventory score demonstrated increased after revascularization: 15 patients mild (26.32%) at time zero to 17 (29.82%) after. And with moderate, seven patients (12.28%) before and 10 (17.54%) after. In the categories of individuals with decreased minimum degree of 32 (56.14%) to 28 (49.12%), and severe of three (5.26%) for two (3.51%) patients. Association was observed between beck depression inventory, gender, age, lifestyle, comorbidities and quality of life. CONCLUSION: There was a high prevalence of elevated beck depression inventory scores, lowest scores of depressive symptoms among men and association between the improvement of quality of life scores and beck depression invento
Acesso aberto (Open Access)
Proposta de intervenção para sensibilização dos gestores municipais quanto à implementação do serviço de acupuntura na saúde mental do municípo Castanhal, Pará
(Universidade Federal do Pará, 2023-05-10) SILVA, Jessé Jerônimo Fernandes e; SILVA, Marcos Valério Santos da; http://lattes.cnpq.br/0379783635000306; https://orcid.org/0000-0002-7824-0042; COSTA, Russany Silva da; http://lattes.cnpq.br/0435018266499256; https://orcid.org/0000-0002-2705-1591
Introduction: Depression encompasses biopsychosocial imbalances and is potentiated by stressful events. The progression of this, restricting quality of life through the exacerbation of negative symptoms and escape and avoidance behavior. Among the treatment approaches, acupuncture has proven effective for therapeutic success Objective: Application of the acupuncture technique in patients with depression disorder as an intervention proposal to sensitize municipal managers regarding the implementation of the mental health service in the municipality of Castanhal, Pará. Method: This was a quasi-experimental study with a quanti-qualitative approach, without a control group, with 17 participants. The data collection used a sociodemographic questionnaire, acupuncture form, Hamilton Scale, SF-12 Quality of Life questionnaire and field diary, the latter categorized into three domains, "quality of sleep", "quality of life" and "anxiety". Nine sessions were performed with a maximum use of 20 needles in each session. The data obtained were analyzed by descriptive statistics with the aid of SPSS software, using the chi-square test and the Student's t-test. Results: The majority of participants were female, in the age range 31 to 40 years, married, high school education, no fixed income, practice evangelism, perform household labor activities, have no children, smoker, sedentary, with unstable relationship in childhood and sexual abuse. The results showed improvement in the signs and symptoms associated with depression with a reduction in the Hamilton score from 19.3 ± 3.77 to 13.13 ± 2.43, student's t=5.6830, p=0.001, besides the improvement in the perception of general health status from the SF-12 from 4.06 ± 1.09 to 1.86 ± 0.83, p=0.001. Conclusion: The intervention with systemic acupuncture showed effective results in patients with depression, besides reducing complaints of anxiety crisis, improvement in sleep quality and concentration of the participants.
Acesso aberto (Open Access)
Sintomas depressivos, declínio cognitivo e prejuízo funcional em idosos
(Universidade Federal do Pará, 2017) UCHÔA, Verediana Sousa; OLIVEIRA, Marília de Fátima Vieira de; http://lattes.cnpq.br/7030765721580568; https://orcid.org/0000-0003-4303-9434
INTRODUCTION: Population aging is considered a worldwide demographic phenomenon. In Brazil we specifically observed a rapid and consistent demographic expansion in the elderly population, the country counts with about 21 million people aged 60 years or more, representing a significant portion of the total population, approximately 11.3%. As a consequence of this change in the age pyramid, we have the increased prevalence of chronic non-communicable diseases, which in turn can lead to functional disability. In addition to chronic diseases, mental health deserves special attention, as they often affect the elderly, with dementia and depression being the most prevalent. Understanding the factors associated with the incidence of depression, as well as the functional and cognitive impairments resulting from this condition, allow us to assist in the prevention and early identification of these symptoms, promoting specific intervention strategies in order to avoid or minimize damages to the quality of life of the elderly. OBJECTIVES: To identify the presence of depressive symptoms, cognitive decline and functional impairment in the elderly enrolled in the program for the control of hypertension and diabetes mellitus of the Municipal Health Unit of Guamá, in the city of Belém, Pará. METHOD: Cross-sectional study with a sample of 100 The elderly. Data were collected through individual interviews using the Mini Mental State Examination (MMSE), the Geriatric Depression Scale (GDS-15), the Katz Scale (ABVD) and the Lawton and Brody Scale (AIVD) for the evaluation of Cognitive ability, presence of depressive symptoms and functional capacity, respectively. Pearson's Chi-square test for trend / adhesion and association between nominal variables and Pearson's Linear Correlation test were used for numerical variables. RESULTS: The profile of the studied population is predominantly female, with low educational level, low income and age range between 60-69 years. The prevalence of depression was estimated in 22% of the sample and was associated with female and sedentary elderly individuals. Regarding mental status, cognitive deficit was identified in 27% of the interviewed elderly, and the age of the elderly presented a moderate negative correlation with the MMSE performance. Regarding the functionality of the elderly interviewed, most of them were considered independent to perform basic activities of daily living, and 46% of the sample had dependence on the instrumental activities of daily living. There was an association between depressive symptoms and functional dependence. CONCLUSION: It was verified that sedentary women and elderly people are more susceptible to the occurrence of depression and that age is a factor strongly associated with a decrease in cognitive performance. It was also observed that the level of dependence of the elderly in the AIVD is strongly associated with the presence of depressive symptoms.