Navegando por Assunto "Fitoterapia"

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Acesso aberto (Open Access)
Análise do remédio artesanal “tintura de pata-de-vaca” tendo a tintura de Bauhinia monandra Kurz como referência
(Universidade Federal do Pará, 2016-03-17) SILVA, Ana Paula Paiva da; SILVA, Marcos Valério Santos da; http://lattes.cnpq.br/0379783635000306; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Diabetes mellitus is one of the various pathologies can be controlled with the use of medicinal plants, which exhibit hypoglycemic activity through different mechanisms. In Marudá, Marapanim-PA, the Women's Group "Erva Vida", produces and markets the "Tintura de pata-de-vaca" consumed by tourists and locals to treat diabetes. This remedy is prepared from leaves of Bauhinia monandra Kurz (pata-de-vaca). Different metabolic classes of plant already had a proven hypoglycemic action, for example flavonoids. Thus, the aim of this study was to characterize the handmade medicine through pharmacobotanic parameters pharmacognostic, phytochemicals and chromatographic in compararação with a tincture of Bauhinia monandra, for the presence of flavonoids. Both the preliminary phytochemical analysis, and the analysis by Thin Layer Chromatography, phenolic metabolites detected, possibly flavonoids in handmade medicine and hydroethanolic extract of plant species. In the analysis by HPLC, it revealed the presence of rutin in handmade medicine as well as in hydroethanolic extract of Bauhinia monandra.
Acesso aberto (Open Access)
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju
(2012-02) VANDERLINDE, Frederico Argollo; ROCHA, Fabio Fagundes da; MALVAR, David do Carmo; FERREIRA, Raquel Teixeira; COSTA, Elson Alves; FLORENTINO, Iziara Ferreira; GUILHON, Giselle Maria Skelding Pinheiro; LIMA, Thereza Christina Monteiro de
Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.
Acesso aberto (Open Access)
Antraquinonas e naftoquinonas do caule de um espécime de reflorestamento de Tectona grandi (Verbenaceae)
(2006-09) MOREIRA, Rafael Yasunori Okada; ARRUDA, Mara Silvia Pinheiro; ARRUDA, Alberto Cardoso; SANTOS, Lourivaldo da Silva; MÜLLER, Adolfo Henrique; GUILHON, Giselle Maria Skelding Pinheiro; SANTOS, Alberdan Silva; TEREZO, Evaristo
The hexane extract of the bark of Tectona grandis (Verbenaceae) afforded two anthraquinones and two naphtoquinones. Their caracterizations were obtained through NMR spectroscopic techniques. This is the first phytochemical study of the bark of Tectona grandis reforestation specimen in Brazil. The main interest in this work is proving the presence of tectoquinone in reforestation specimen.
Acesso aberto (Open Access)
Avaliação de minerais em plantas medicinais amazônicas
(2009-06) MARTINS, Alexsandro Sozar; ALVES, Claudio Nahum; LAMEIRA, Osmar Alves; SANTOS, Alberdan Silva; MÜLLER, Regina Celi Sarkis
The Amazonian Brazilian offers an appreciable potential of plants with therapeutic properties, although most are little known. In this way, with the objective of verifying the potentiality nutritional of medicinal herbs, a work was developed to determine the concentration of Ca, Mg, Fe, Cu and Zn in the leaves and in the teas of these species: Piper callosum Ruiz & Pav., Piperaceae, Mikania lindleyana DC., Asteraceae e Arrabidaea chica (Humb. & Bonpl.) B. Verl., Bignoniaceae. After the plants samples have been processed, they were submitted to digestion and soon afterwards the metals were analyzed in an spectrophotometer of Atomic Absorption. The results showed the follow yields: for the tea of Arrabidaea chica Ca were detected (6955 to 20058 mg/L), Mg (2390 to 3094 mg/L) and Fe (40 to 61 mg/L). For the tea of Mikania lindleyana besides the presence of high values of Ca (17722 to 22336 mg/L), Mg (4531 to 9370 mg/L) and Fe (20 to 87 mg/L) they were found from 7 to 16 mg/L of Cu and 9 to 41 mg/L of Zn. The tea of the Piper callosum presented 2036 to 4344 mg/L of Ca, 618 to 4023 mg/L of Mg and 39 to 60 mg/L of Fe. Being compared the results of the minerals with the values recommended by the Health World Organization, is possible that the present metals in the teas of the plants could contribute in the complementation of the people's alimentary diets that use these medicinal plants.
Acesso aberto (Open Access)
Avaliação in vitro do potencial genotóxico e citotóxico do extrato do açaí (Euterpe oleracea) clarificado sobre a linhagem celular AGP01 (câncer gástrico)
(Universidade Federal do Pará, 2024-01) SANTOS, Thiago Souza; BAHIA, Marcelo de Oliveira; http://lattes.cnpq.br/3219037174956649; BURBANO, Rommel Mario Rodríguez; http://lattes.cnpq.br/4362051219348099; https://orcid.org/0000-0002-4872-234X
Açaí (Euterpe oleracea MART) is a fruit of great importance for the Amazon region in nutritional, cultural and socioeconomic terms. In recent years, açaí has been the subject of several studies due to its beneficial properties for health, including effects against tumor cells. Therefore, the present work aimed to evaluate in vitro the genotoxic and cytotoxic effects of the clarified extract of açaí juice in a human metastatic gastric cancer cell line (AGP01 cells). For comparison purposes, a non-transformed cell line of African green monkey renal epithelial cells (VERO cells) was used. The viability assay by resazurin reduction, the comet assay, the determination of cell death by differential fluorescent dyes and the wound healing migration assay were performed. A reduction in viability was observed only in the AGP01 line within 72h. There was no genotoxic damage or cell death (through apoptosis or necrosis) in any of the cell lines. However, açaí extract induced motility reduction in both cell lines. The reduction in cell viability and the induction of the anti-migratory effect in the AGP01 cell line opens perspectives for exploring the potential of Euterpe oleracea as an adjuvant in the treatment of gastric cancer.
Acesso aberto (Open Access)
Caracterização química e físico-química e estudos preliminares de planejamento da formulação fitoterápica semi-sólida contendo tintura de Calendula officinalis L.
(Universidade Federal do Pará, 2008-12-29) NUNES, Kariane Mendes; SILVA JÚNIOR, José Otávio Carréra; http://lattes.cnpq.br/4437885351749994
The phytotherapy is a form of medicinal therapy that has been grown noticeably over the years, however, despite the broad use of phytomedicines, the quality of these drugs is often poor and questionable. Among the several medicinal plants used as herbal medicine, the Calendula officinalis L. is known for its anti-inflammatory, antiseptic and healing effects. Thus, this present study aimed to enhance and consolidate the use of methods of pharmaceutical technology in the development of phytotherapeutic agents, through the completion of preliminary studies of the planning of a semi-solid formulation phytotherapic containing tincture of Calendula officinalis L., for the quality control of the stages of their development. In the physical characterization and physical chemistry of the dust and tincture of calendula were obtained farmacognóstics specifications consistent with the literature, and to establish the identity of the plant material through the detection of the chemical marker rutin by Thin-Layer Chromatography (TLC). Through the validation of the method, that presented parameters recommended by existing legislation, was given 463 μg/mL of rutin in tincture. The infrared (IR) spectra showed characteristics of rutin in the lyophilised extract, in addition to demonstrate the permanence of these bands after mixing with the excipients of the formulation. The thermoanalytic techniques confirmed the compatibility between the excipients and lyophilisate of calendula extract. In the preliminary assessment of the stability of the gel formulation remained stable during the cycles in greenhouse (45 ± 2 0C) and temperature (25 ± 2 0C). In the preliminary study of the gel, permeation tended to favor the permeation of total flavonoids as rutin for receiving phase. These results demonstrate the importance of employment of protocols for quality control of raw materials plant, besides the establishment of technological methods for the production of phytotherapic.
Acesso aberto (Open Access)
Controle alternativo de helmintos de Astyanax cf. zonatus utilizando fitoterapia com sementes de abóbora (Cucurbita maxima) e mamão (Carica papaya)
(2012-01) FUJIMOTO, Rodrigo Yudi; CORDEIRO, Helrik da Costa; RAMOS, Fabrício Menezes
The objective of this study was to evaluate the effectiveness of an alternative method with pumpkin and papaya seeds, dried and ground, for control of helminth parasites of Astyanax cf. zonatus. Sixty fish were distributed into twelve containers, with one fish/liter. The experiment consisted of four treatments and three replications: TJ = fish in fasting; TRC = fish fed with commercial diet; TSA = fish fed ad libitum with pumpkin seed, and TSM = fish fed ad libitum with papaya seeds. After seven days of feeding, all fish were weighed and blood was taken for blood smears. Efficacy was determined by checking the presence of parasites in the gills, stomach and intestine, in 40% of fishes per treatment (n=6). TJ and TSM showed 39% and 25% of weight loss respectively. The TSA showed better efficacy against the nematode in intestine and stomach (95.26% and 92.48%). The TSM promoted 72% of efficiency on monogeneans control. Hematology revealed an increase of monocyte values to treatment TSM. A decrease of eosinophil values was observed in treatments TSA, TSM and TRC. Thus, feeding fishes with pumpkin is a effective alternative method of low cost for control of nematodes in Astianax cf. zonatus.
Acesso aberto (Open Access)
Desenvolvimento de um método para caracterização do extrato hidroetanólico das folhas de Mikania lindleyana DC por Cromatografia Líquida de Alta Eficiência (CLAE)
(Universidade Federal do Pará, 2011) OWITI, Alex Oselu; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Mikania lindleyana DC (Asteraceae), vernacular “Sucuriju”, is a creeping, shrubby, perennial, evergreen plant, growing in the Amazon region where it is used as diuretic, anti-hypertensive, anti-inflammatory and anti-ulcerous medicine. The main aim of this study was to develop a method for characterization of hydro-ethanolic extract (tincture) from the leaves of M. lindleyana DC, using UV and High performance Liquid Chromatography (HPLC). The hydro-ethanolic extract (tincture) was prepared based on Brazilian Pharmacopeia V, 2010 and its dry residue was submitted to phytochemical analyses, Thin Layer Chromatography (TLC) and High Performance Liquid chromatography (HPLC). Among the substances observed in the phytochemical analysis was coumarin, alkaloids, amino acids, reducing sugars, phenols, tannins, steroids, terpenes, saponins and organic acids. TLC test was done by applying hexanic, chloroformic and ethyl acetate Fractions together with Crude hydro-ethanolic extract and aqueous solution of coumarin Aldrich® 0,1mg/ml on the same plate using toluene/dichloromethane/acetone (45:25:30) as the eluent system. The chromatogram was then sprayed with an alcoholic solution of KOH 5%, and then observed under UV light at 254nm and 365 nm, revealing a light green band at an RF-0.61 for chloroformic fraction, crude hydro-ethanolic extract and for coumarin samples. The HPLC analysis was conducted using methanol/water 53:47 as the eluent system. The chloroformic fraction(CL), coumarin and the crude hydro-ethanolic extract (CHE) showed peaks at Retention time around 6.00minutes and spectra with maximum absorptions between 270nm and 300nm.This clearly demonstrate the presence of coumarins in the samples (CL= 0.209mg/mL and CHE= 0.014mg/mL).
Acesso aberto (Open Access)
Diretrizes para a criação de um arranjo produtivo local de plantas medicinais e fitoterápicos em Marapanim-PA
(Universidade Federal do Pará, 2018-04-04) PINHEIRO, Ailton Castro; VASCONCELLOS SOBRINHO, Mário; http://lattes.cnpq.br/7843288526039148; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
In 2006, Brazil started its national policy of medicinal plants and phytomedicines, which includes 17 guidelines to rule actions in different segments of the phytotherapy. In 2008, to implement this policy a program was organized, which links four of these guidelines to specific actions in phytotherapy, based on traditional and popular knowledge and familiar agriculture, to determine that the Ministries involved develop actions in an integrated way, in order to enable production, and marketing, by the community itself. In 2012, the Health Ministry (HS) begun financing the pharmaceutical assistance with medicinal plants and phytomedicines, being the Local Productive Arrangement (LPA) one of the available instruments. In Amazonian State Pará, from 2012 to 2017, only four municipalities applied, and have approved, such projects by the Ministry of Health. The Municipality of Marapanim (PA) has a great ethnopharmaceutical potential, with emphasis on the work of a group of women, who practice the popular phytotherapy for more than 20 years, based on the knowledge of their ancestors. They produce handcrafted remedies combining popular knowledge with technical knowledge, in partnership with the Laboratory of Ethnopharmacy of the Nucleus of Environment of the Federal University of Pará (LAEF/ NUMA/UFPA). In this context, the aim of this work is to elaborate, and propose, guidelines to build a Local Productive Arrangement in Marapanim that can allow the insertion of phytomedicines used in folk phytotherapy in the institutional market, after a technical adequation, and thereby contributing to the territorial and endogenous development of the municipality. In order to reach this objective, a bibliographic survey was carried out based on dissertations written by members of the LAEF/NUMA/UFPA, whose set compose an important diagnosis of the reality of local herbal phytotherapy. This bibliographic survey was complemented by a documentary research in the Transparency Portal of the municipality; interviews with the Marapanim healers and participation in LAEF/NUMA/UFPA actions in favor of the valorization of local phytotherapy; study about some APL experiences, financed by MS and the analysis of the technical regulation and as well of the financial suport destined to phytotherapy. The analysis of these data was performed using the theoretical framework of territorial and endogenous development, of the National Policy and National Program of Medicinal Plants and Phytomedicine, and of the traditional and popular knowledge. As a result, this work proposes eleven guidelines for building an APL involving: initial articulation for the construction of an APL project; articulation along the implementation of the APL, training; sowing of medicinal plants, production of phytomedicine; public -private partnership for marketing in the institutional market; marketing in the private market; dispensing in the SUS; planning and budget execution of fund-to-fund resource; institutionalization of a municipal phytotherapy program, and proposal of a flow chart for APL governance. The following products were also generated: a project model to obtain resource from MS for financing an APL and a new redaction of the administrative regulation of MS nº 1,555 / 2013.
Acesso aberto (Open Access)
Documentação e valorização da fitoterapia tradicional Kayapó nas aldeias A'Ukre e Pykanu - Sudeste do Pará
(2003) BARBOSA, Wagner Luiz Ramos; PINTO, Lucianna do Nascimento
In the beginning of 1996 researchers from the program Poverty and Environment in Amazon visited the Kayapó villages A'Ukre and Pykanu in the southern of Pará State - Brazil These expeditions also aimed to rescue the kayapó phytotherapeutical tradition in the villages and to identify plant species with pharmaceutical potential. Six shamans were interviewed with translation three at each village. The shaman presented fiftythree different plants from, which twenty had elucidated their botanical identification on basis of photography
Acesso aberto (Open Access)
Efeito do tratamento combinado com laserterapia e gel de açaí na fase proliferativa de reparo em modelo de lesão por ruptura tendínea total em ratos
(Universidade Federal do Pará, 2023-08-13) MENDES, Aurea Gabriela Rodrigues; MORAES, Suellen Alessandra Soares de; http://lattes.cnpq.br/6278397231382779; BATISTA, Evander de Jesus Oliveira; http://lattes.cnpq.br/2206444845201080
Acai extract has been investigated as a pharmacological strategy due to its anti- inflammatory, antioxidant and antinociceptive effects. Furthermore, studies report that low-intensity laser (LBT) may favor tissue repair due to its proliferative effects in increasing the number of fibroblasts and collagen synthesis. Therefore, the combined use of açaí with LBT may be a therapeutic alternative in the management of tendon repair. The aim of this study was to evaluate the effects of combined treatment with açaí gel and LBT on the morphofunctional and nociceptive aspects of Achilles tendon injury in the proliferative phase of repair. For this, 40 Wistar rats were divided into control group (CTRL), injury (INJURY), 10% açaí gel (INJURY+GA), 2J infrared laser, (INJURY+LAS) and combined treatment (INJURY+LAS+GA). The Von Frey test, Joint Angle and Achilles Functional Index were performed at 0-, 3-, 7- , and 14-days post-injury (DPL). After 14 days, the tendons were collected and the tissue organization pattern was analyzed by H&E or Alcian Blue to assess variations in glycosaminoglycans in the extracellular matrix, staining with DAPI to quantify the number of cells and collagen autofluorescence to assess the orientation pattern of collagen fibers. We demonstrated improvement in the macroscopic characteristics of the tendon in the treatment groups in relation to INJURY, which may be correlated with better organization and tissue orientation, as well as collagen fibers in these groups. The increase in the number of cells and fibroblasts was more evident in the laser group, emphasizing the proliferative role of the laser. Functional recovery was observed in 7 DPL in the isolated laser group, while the combined treatment improved nociception in the acute phase (7th DPL). In the proliferative phase (14th DPL), the IFA showed improvement in functional aspects in the combined treatment group. On the other hand, nociceptive sensitivity was reestablished in all treatment groups. In summary, our findings indicate that the combined use of açaí gel with LBT may be a therapeutic alternative in the management of tendon injury repair.
Acesso aberto (Open Access)
Fitoterapia popular do bairro do Sossego distrito de Marudá-Pará
(Universidade Federal do Pará, 2014-03-07) FLOR, Alessandra Simone Santos de Oliveira; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
In the Amazon medicinal plants are a mare resource for the treatment of various diseases, given the cultural context, access, reliability and low cost compared to industrial medicine. This context, is the Marudá District, in the municipality of Marapanim distant 160 km from the Belém state of Pará, where it is common to use medicinal plants to treat health problems. In Brazil has shown several surveys of plant species used in folk phytotherapy of a human group, applying methodologies such as ethnobotany and etnopharmacy to inventory the plant species. This work aims to investigate the practice of folk herbal medicine by the residents of the Quiet neighborhood, including a group of women called Herb Life Marudá District state of Pará, highlighting the importance of medicinal plants for this human group in cultural, economic and environmental terms. For this we carried out in the ethnopharmaceutical survey medicinal plants used by local people. To perform the work of 18 popular herbal medicine practitioners who were nominated by the community’s itself in Quiet Neighborhood (holders of knowledge about medicinal plants people) were interviewed following the "Snow Ball" technique. Women's Group Life Herb, being also in possession of knowledge on medicinal plants were also interviewed. Were cited 96 ethnospecies for medical, according to informants, they are distributed in 44 families, highlighting the Lamiaceae with 11 ethnospecies (11,70%) and Asteraceae, with 7 ethnospecies (7,44%). The most cited grievance is fever, treated with Anador plant having the highest relative frequency of use claim (FRAPS), 100% of the votes, followed with 88% of rue to treat headache. These two plants have potential for more drug to validate their claims folk usage studies. This paper reports the popular wisdom about folk herbal medicine practiced in Quiet neighborhood, Marudá - Marapanim, PA and provides insights for future projects for the development of place productive arrangements with herbal medicines and the use of drugs prepared by Herb Life Group at attention basic health thus inducing the District Place Development in Marudá.
Acesso aberto (Open Access)
Fitoterapia popular: uma abordagem sobre a etnotoxicologia das práticas fitoterápicas no distrito de Marudá – Marapanim/Pará
(Universidade Federal do Pará, 2014-11-25) OLIVEIRA, Nayana Véras Jardim de; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
The dissertation propose the expansion of the existent theoretical outline about the medicinal plants amid the Amazon regional context, from the social actors’ perception related to the phytotherapy practice in the studied area, Marudá’s District (Marapanim – Pará). Specifically, it discusses the proposal of a new approach, the ethnotoxicology, for the capture and evaluation of data related to the undesired effects attributed to the use of the phytotherapic. The specific goals were: to raise ethnotoxicological data related to phytoterapy’s practice, to systematize the information related to medicinal plants, which were mentioned by the interviewed groups, to describe the security profile for the phytotherapy that is practiced in Marudá from the Ethnotoxicology and to elaborate a VadeMecum to the referred medicinal plants, in conjunction with previous academic productions. The information was collected from field interviews made with a group of 10 people shared three groups: local nurses, herb women from the group Life’s Herb and local users and tourists. In this work, the guiding proposal points a real analysis, by a relatively new side, which interlines the data collect in the phytotherapy practitioner’s perception, taking in consideration the reality in which each individual is inserted. The dissertation emerges the interviewed group perception about the associated risks to the indiscriminated phytotherapy practice, in order to contribute to the expansion of the theoretical outline related to the theme, consolidation of a safe praxis and action’s effectuation, within the public politics of health attention, with respect to the use of plants as a therapeutic resource; therefore promoting the safe phytotherapy development not only in Marudá’s area, but also in other communities that develop similar activities.
Acesso aberto (Open Access)
Fitoterapia solidária - Uma proposta sustentável para a atenção básica em saúde e o desenvolvimento local
(Universidade Federal do Pará, 2012-10-11) SILVA JÚNIOR, Miguel Rodrigues da; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
According to the World Health Organization (WHO), medications are essential tools for health care. This importance is recognized by the Brazilian government, which in Law 8080 stipulates that ensure integrated care, including pharmaceuticals, composes an explicit function of the Unified Health System (SUS). However, although they constitute the greatest advance in health, access to medicines is extremely polarized due to multiple factors, among which we emphasize in this study the high prices charged by the pharmaceutical industry - which anchored the capitalist paradigm of "development", focuses medicines according to economic power of individuals and nations. As a way to overcome this problem that affects all countries, especially developing ones, WHO, since the Alma-Ata in 1978, has strongly recommended the inclusion of herbal medicine systems health officials of its member members, in order to increase people's access to resources pharmacists effective, safe and quality. In this sense, among other initiatives, the Brazilian government implemented the National Policy on Medicinal Plants and Herbs (PNPMF), which, in our view, search, basically, increase access to medicinal plants and herbal medicines from the increased production of these treatment options, and current pharmaceutical capitalists as a driving force in this process. However, this study highlights that increase the production of medicinal plants and herbal medicines does not necessarily guarantee increased access in a perspective of universality, comprehensiveness and equity, so little is that production is concentrated in existing pharmaceutical companies private, whether they national or international. Thus, while pointing out some of the possible socio-economic impacts related to the production of medicinal plants and herbal medicines primarily in capitalist ventures, this study back to discuss the production of these therapeutic options, too, on developments that integrate the Solidarity Economy - that by the way, originated the term Phytotherapy Solidarity, coined in this study - as an alternative aimed to provide both increased access to medicinal plants and herbal medicines, as the Local Development, pointing to local actors not only as suppliers of raw materials for larger pharmaceutical companies, as advocates implicitly PNPMF, but also finished products to the NHS and to the general population - in a perspective of achieving more affordable. Finally, take as an example the city of Para-Igarapé Miri as potential for the development of herbal products (initially, herbal tampered with) in accordance with the ideals of solidarity phytotherapy - highlighting the advantages and obstacles presented by this municipality, well as possible ways to mitigate them. So, ultimately, this paper aims to contribute in the process of decision making of public managers and other professionals involved with PNPMF regarding sustainable development chain and production arrangements of medicinal plants and herbal medicines, as well as the insertion process these therapeutic options in SUS, to harmonize national economic interests with the therapeutic needs of the brazilian population.
Acesso aberto (Open Access)
Fitoterapia tradicional por meio do uso da planta “insulina” (Cissus Verticillata), no tratamento do diabetes mellitus, em uma comunidade costeira do nordeste do Pará (Amazônia, Brasil)
(Universidade Federal do Pará, 2020-07-30) MORAES, Jones Souza; SILVA, Iracely Rodrigues da; http://lattes.cnpq.br/5393264898435715; OLIVEIRA, Euzébio de; http://lattes.cnpq.br/1807260041420782; https://orcid.org/0000-0001-8059-5902
The Caeté river basin, situated in northern Brazil, that belongs to the Brazilian Amazonia region, Northeast of the Pará State, presents a large number of plant species with varied medicinal properties, widely used by residents of the region's traditional populations, highlighted in this case, for the traditional riverside/coastal populations that live there. Nevertheless, a lot of these plants have not yet been identified or had their medical uses registered in traditional ways. This study aimed to analyze the therapeutic/medicinal uses of the plant's ethno species Cissus verticillata, popularly known as “Insulin”, in treatment of the Mellitus Diabetes, on the riverside/coastal community of Ponta de Urumajó NE of Pará. The research presents a qualitative methodological approach, realized through the field research, using as the instruments of collection of data, the application of free listing, interviews with key-informers, application of forms, collection of vegetable samples, observation, recording of audio/video and pictures. Results point out that the community of Ponta do Urumajó demonstrates a great knowledge about medicinal plants, using it in the most diverse ways, in addition, of course, to know, with great propriety, the practices used for the use of medicinal plants, that are used for health care, which in this case is the Cissus verticillata, that is used for the treatment of Mellitus Diabetes. The community has been using “Insulin” widely, however, not knowing if this plant has any toxic effect and/or danger of adverse reactions. To that end, the conclusion of this work tends to contribute to the recognition and appreciation of the knowledge and local practices of traditional riverside/coastal populations in the Brazilian Amazonia, in relation to the use of medicinal plants, as well as seeking a greater integration between scientific and traditional knowledge to the consolidation of species conservation practices, such as its safe medicinal use, giving quality of life to diabetic patients.
Acesso aberto (Open Access)
A influência da utilização de plantas medicinais nos custos do tratamento de agravos atendidos pela assistência farmacêutica básica
(Universidade Federal do Pará, 2010-10-26) RÉCIO, Eveline de Jesus Pereira; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
The use of medicinal plants for the treatment of the ailments of health is disseminated not only in the rural areas but also in the urban areas of the Brazilian territory. The economic meaning of these medicinal plants, used in the attendance of the basic health needs, for the home economics of the socially vulnerable part of the population, is still poorly investigated. Many plant’s species are commercialized in the city of Belem by herbalists in markets and open fairs of the city. This article has as objective analyze in what extent the insertion of the use of medicinal plant minimizes the costs of the treatments of injuries treated by the Assistencia Farmaceutica na Atencao Basica (Pharmaceutical Assistance in the Basic Attention). To achieve this objective, it was realized a study, of exploratory nature, by means of application of questionnaires, using the method of sampling, defined by non-probabilistic criteria, in the district of Jurunas, with support in the Unidade de Saude Radional II (Health Unit Radional II), located in the metropolitan region of Belem, Para. It was made a survey of informations regarding the focus of this study in the Centro de Referencia de Tratamento Natural (Natural Treatment Reference Center - CRTN), located in the city of Macapa, that already utilizes the medicinal plants as a therapeutic resource. In the result of the field research in the district of Jurunas it was verified that approximately 50% of the interviewed practice the self-medication with medicinal plants, listed in the RDC nº 10/ANVISA, been needed, however, correct orientation for its growth and therapeutic use. The comparison between expenses with synthetic medicines in the treatment of the symptoms of five diseases that frequently occur in district of Jurunas and those resultants of the use of medicinal plants, for the same symptoms, reveals a reduction in the expenses for treatments based on medicinal plants. In conclusion, it can be inferred that this reduction represents a saving of resources that the user and the system leave to expend when utilizes the medicinal plants.
Acesso aberto (Open Access)
Isolamento e quantificação de flavonóides e abordagem das atividades antioxidante e antimicrobiana de Jatropha gossypiifolia L.
(Universidade Federal do Pará, 2008-12-30) VEIGA, Andrex Augusto Silva da; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Jatropha gossypiifolia L (Euphobeaceae), known in Pará as “Pião roxo” is used for treatment of hemorroids, burns, stomach pains among other diseases, the importance of this plant to this region has led to its research in order to improve its phytotherapeutic development. During the analysis, the chromatographic profiles of its Crude Ethanolic Extract (CEE)was determined using Thin Layer chromatography (TLC) and High Performance Liquid Chromatography (HPLC) methods. The total and isolated flavonoids quantities were determined. Antimicrobial activity essays of the crude ethanolic extract were also conducted and the fractions obtained (hexanic, chloroform, ethyl acetate and residual fractions). The antioxidant activities of the extract and the fractions were also characterized. The plant materials were collected from EMBRAPA medicinal plants garden in the east Amazon and then extracted through percolation to obtain crude ethanolic extract. The dry extract was obtained using low pressure rotative evaporator followed by liquid-liquid partition with hexane, chloroform and ethyl acetate successively. The fractions obtained were also concentrated at low pressure, The ethyl acetate fractions were re-fractioned, giving rise to acetone fraction (ActF-II), a new ethyl acetate (AF-II), methanolic fraction (MF-II) and a solid residue (SR-II). ActF-II was submitted to liquid chromatography at average pressure, resulting in sub-fractions like Fr ActS-II and Fr ActS3-II called Jg1 and Jg2, respectively. Chemical prospection of the Extract and the metabolite fractions were conducted in triplicates, leading to the observation of the presence of the following polyphenols: Catechines, Tannins and flavonoids. The analysis by thin Layer Chromatography (TLC) was conducted using eluent of ethyl acetate/formic acid/glacial acetic acid/water at (100:11:11:26) on a normal phase silica gel, showing the retention factors in the following zones:0.65, 0.72, and 0.77 in reaction to Fecl3 solution . The HPLC chromatogram of ethanolic crude extract presented three significant peaks with average values of RT: 13.2 min, 15.02 min, and 16.00 min whose spectra are characteristics of flavonoids. On calculating the flavonoid quantity using the average absorbance reading (A=0.874), 2.02% flavonoid was found. The concentrations for each isolated substances was 340ug for Jg1 and 406 ug for Jg2 per milliliter of extract solution. Regarding the biological activity tested AF-1 and Fr-1 inhibited growths of S. aureus and C.albicans and also manifested a great antioxidant potential. These results provide adequate polyphenol parameters for quality control serving as chemical markers and their possible quantities.
Acesso aberto (Open Access)
Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids
(2009-12) OLIVEIRA, Alaíde Braga de; DOLABELA, Maria Fâni; BRAGA, Fernão Castro; JÁCOME, Rose Lisieux Ribeiro Paiva; VAROTTI, Fernando de Pilla; PÓVOA, Marinete Marins
Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in vitro and in vivo assays as well as bioguided isolation of active compounds. The final products would be antimalarial chemical entities, potential new drugs or templates for new drugs development, and/or standardized antimalarial extracts which are required for pre-clinical and clinical studies when the aim is the development of effective and safe phythomedicines. This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalarial drugs or leads and chemical markers for phytomedicines.
Acesso aberto (Open Access)
Plantas medicinais e fitoterápicos no município de Marapanim-PA: qualificação da atenção básica e desenvolvimento local
(Universidade Federal do Pará, 2015-08-28) SANTOS JÚNIOR, Roque Flor dos; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
Medicinal plants in the Amazon have always had an important role, because they are used as one of the major therapeutic resources in disease treatments. The city of Marapanim-PA is 161 Km from the State capital of Pará and is characterized by presenting, through information obtained by its inhabitants, great affinity with the use of medicinal plants as a therapeutic option. In Brazil, there are several consolidated experiences of municipal programs and projects of use of medicinal plants as a complementary practice in the Unified National Health System (SUS), however in Marapanim-PA, still no program for insertion of this therapeutic resource in the basic attention in health. This work aims to outline the profile of the users of the basic attention to health, noting the frequency of use of medicinal plants and their claims, in addition to emphasizing the importance of medicinal plants while local resource of community health. This work consisted on information survey in two phases: the first held interviews with healthcare professionals in primary care, ending with interviews with users. Were collected informations from groups, transformed into data, charts and tables, summarizing the opinion of 185 people, being 150 users and 35 health professionals. The results of the interviews revealed that all users were in favour of the inclusion of medicinal plants in the primary health care units, this confirmation was also retrieved from health professionals, with the exception of dentists due to their lack of knowledge about herbal medicines, their effectiveness and toxicity. Another important work is the expectation of all respondents for the implementation of a Municipal Program of Medicinal Plants and Phytotherapeutics. This work revealed that medicinal plants are relevant in the daily lives of users of public health services as a therapeutic resource. This work brings as a contribution to the process a procedures booklet with guidelines that will serve as an initial step for the development of a productive chain in the field of medicinal plants in the city.
Acesso aberto (Open Access)
Plantas medicinais utilizadas em comunidades do município de Igarapé-Miri, Pará: etnofarmácia do município de Igarapé-Miri-Pará
(Universidade Federal do Pará, 2008-08-08) PINTO, Lucianna do Nascimento; BARBOSA, Wagner Luiz Ramos; http://lattes.cnpq.br/1372405563294070
In IgarapéMiri, as well throughout the state of Pará, the use of medicinal plants to treat many illnesses is very usual. In the same way, in some states in Brazil official programs of medicinal plants have been registered and to follow the plant species used in the folk phytotherapy ethnoguided methodologies are applied mainly ethnobotany and ethnopharmacology. From the Pharmaceutical Sciences Ethopharmacy was elaborated, which has been worldwide used to approach medicinal plants and to evaluate the remedies prepared from them. The general aim of this work is to contribute for the consolidation of Ethnopharmacy and the implementation of the PNPMF in the state of Pará, bringing information collected about indication of medicinal plants, preparation and administration of vegetal remedies and problems related to the use of them. More specifically, it aims to determine the regional nosogeography, to identify and to select the used phytotherapeutical resources for the treatment of the prevalent illnesses, to know and to characterise from the pharmaceutical point of view the remedies made with vegetable base, as well as elaborating cards with information about selected vegetables, these are other objectives considered here. The tool to reach these objectives is the ethnopharmaceutical survey which associates elements of other ethnoguided methods with the content of the Pharmaceutical Care. Applied in eighty six communities of the city, at two moments, first in the year 2000 and in March/April 2008, the method supplied data which were tabulated using Excel to make tables and graphs. Thus, 91 illnesses, 236 plants species, distributed through 72 botanical families, and in 7 different forms of administration. Thirty eight adverse events could also be identified. Cards with botanical, chemical and ethnopharmaceutical information were elaborated for the four plants species with highest relative citation frequencies.