Navegando por Assunto "Lippia origanoides"

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Acesso aberto (Open Access)
Avaliação anticonvulsivante e pró-convulsivante de óleos essenciais de Lippia origanoides e Rosmarinus officinalis em ratos: um estudoeletrofisiológico
(Universidade Federal do Pará, 2025-05) ARAÚJO, Daniella Bastos de; HAMOY, Moisés; http://lattes.cnpq.br/4523340329253911; https://orcid.org/0000-0002-2931-4324
Epilepsy is a neuronal disorder characterized by abnormal brain excitability, leading to seizures. Only about 66% of epileptic patients respond adequately to treatment with existing conventional anticonvulsants, making it necessary to investigate new antiepileptic drugs. The growing research on natural products and their pharmacological properties has become increasingly promising, particularly in the study of essential oils, already widely used in popular culture for the treatment of several diseases. The present studies evaluated the anti- and pro-convulsant effects of the essential oils of Lippia origanoides (LOEO) and Rosmarinus officinalis (EORO) in Wistar rats. We evaluated the essential oil of Lippia origanoides (LOEO) (100 mg/kg i. p.) in comparison with diazepam (DZP) (5 mg/kg i. p.) and the combined administration of these two substances to control seizures induced by pentylenetetrazole (PTZ) (60 mg/kg i. p.). This evaluation was carried out using 108 male Wistar rats, which were divided into two experiments. Experiment 1 – Behavioral evaluation and Experiment 2 – Electrocorticographic evaluation. With rosemary essential oil, we evaluated high doses in 54 Wistar rats, weighing between 180 and 200 g. The study consisted of three experiments: 1) behavioral monitoring of the animals after administration of 500 mg/kg i.p.; 2) electrocorticographic recordings after drug administration; 3) reaction to anticonvulsant drugs, where phenytoin, phenobarbital and diazepam (10 mg/kg i.p.) were administered. With LOEO, the animals presented a more intense decrease in respiratory rate when combined with LOEO + DZP. EEG recordings showed a reduction in firing amplitude in the groups treated with LOEO. Combined treatment with diazepam resulted in increased anticonvulsant effects, while with EORO, the results demonstrated an increase in the latency time for the onset of isolated clonic seizures without loss of the postural reflex. The animals showed a more intense decrease in respiratory rate when combined with LOEO + DZP. EEG recordings showed a reduction in firing amplitude in the groups treated with LOEO. Combined treatment with diazepam resulted in increased anticonvulsant effects. Treatment with LOEO was effective in controlling seizures, and its combination with diazepam may represent a future option for the treatment of difficult-to-control seizures, while treatment with EORO demonstrated an excitatory activity related to the reduction of GABAergic activity.
Acesso aberto (Open Access)
Avaliação da composição química e atividades biológicas dos óleos essenciais de Lippia gracilis e Lippia origanoides da Amazônia oriental
(Universidade Federal do Pará, 2012-10-17) FRANCO, Caroline da Silva; SILVA, Joyce Kelly do Rosário da; http://lattes.cnpq.br/2278686174214080; MAIA, José Guilherme Soares; http://lattes.cnpq.br/1034534634988402
The genus Lippia is known for its aromatic character and medicinal use of its species as an alternative therapy. Essential oils of Lippia gracilis and L. origanoides collected in Pará and Maranhão were obtained by hydrodistillation and were rich in monoterpenes. The major compounds oil of L. gracilis were thymol (72.5%), p-cymene (9.3%) and thymol methyl ether (5.4%); for oil of L. origanoides were thymol (45.8%), p-cymene (14.3%), -terpinene (10.5%) and carvacrol (9.9%). The oils had potential larvicide against Artemia salina with LC50 values of 7.4 ± 0,2 μg.mL-1 to L. origanoides and 18.7 ± 0.2 μg.mL-1 to L. gracilis, both more active than lapachol (EC50 = 21.2 ± 2.2 μg/ ml). The essential oil of L. gracilis showed moderate scavenging capacity DPPH with EC50 value = 35.7 ± 3.32 μg.mL-1 about 8 times less active than the standard trolox (EC50 of 4.5 ± 0.1). Furthermore, the oil L. gracilis proved to be a good natural fungicide against the phytopathogen C. sphaerospermum with limit of detection of 5 μg, about 10 times less active than miconazole (DL = 0.5 μg). Moreover, the oil L. origanoides no showed significant activity (DL = 100μg).