Navegando por Assunto "Transtornos mentais"

Agora exibindo 1 - 4 de 4

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Avaliação de microRNAs circulantes na esquizofrenia: da desregulação epigenômica a potenciais biomarcadores
(Universidade Federal do Pará, 2021-03) RODRIGUES, André Luiz de Souza; BURBANO, Rommel Mario Rodriguéz; http://lattes.cnpq.br/4362051219348099; https://orcid.org/0000-0002-4872-234X
Introduction: Schizophrenia is a serious and complex pathology that affects about 0.5-1% of the world's population. For the clinical diagnosis of schizophrenia, there are clinical criteria to be evaluated, which include both positive and negative symptoms. In the origin of the disease, there is a close relationship between environmental stimuli, and strong evidence shows that these stimuli have the ability to act on epigenetic mechanisms, which act in the regulation of gene expression. MicroRNAs (miRNAs) are stable and potentially reliable biomarkers, and some miRNAs have been previously identified as potential biomarkers for schizophrenia in peripheral samples. Objective: To evaluate the expression profile of circulating miRNA's in patients with schizophrenia (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) in relation to control individuals negative for the disease. Methods: Analytical, case-control, cross- sectional study using samples previously collected from patients diagnosed with Schizophrenia (N = 650) and control group (N = 924), who adequately met the inclusion criteria. The samples were analyzed after RNA extraction through its quantification and techniques for obtaining reverse transcriptase reaction and real-time quantitative polymerase chain reaction. All data were analyzed using IBM SPSS22 statistical program. Results: Using the peripheral blood collection method with the intention of finding possible biomarkers for schizophrenia, an increased expression of the miRNA’s miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652 was observed in several scenarios analyzed, confronting the case and control groups, as well as variables within the case-group, demonstrating potential diagnostic value.
Acesso aberto (Open Access)
Uma crítica à produção do TDAH e a administração de drogas para crianças
(Universidade Federal do Pará, 2016-09) CRUZ, Bruna de Almeida; LEMOS, Flávia Cristina Silveira; PIANI, Pedro Paulo Freire; BRIGAGÃO, Jacqueline Isaac Machado
This article aims to analyze the practice of diagnostics in their effects of producing ADHD as a disorder in children in school period and operate a criticism of indiscriminate referrals to psychiatrists the events that are taken as school problems and transformed into abnormalities. Among the effects of this very common practice today, is the exponential growth of prescription drugs, such as amphetamines to children, causing severe problems in their lives, which should be the subject of an ethical, political, and social problematization. Specifically, the more drug administered in this situation has been methylphenidate and in Brazil, it has been widely sold and used in cases assessed as inattention and restlessness. This article is the result of a graduate degree in psychology research, in progress and are presented in this text, partial results of the work.
Acesso aberto (Open Access)
Discurso moderno e psiquiatria reformada: considerações sobre um Centro de Atenção Psicossocial (CAPS)
(Universidade Federal do Pará, 2011) QUEBRA, Sâmea Carolina Ferreira; CHAVES, Ernani Pinheiro; http://lattes.cnpq.br/5741253213910825
This dissertation aims to discuss the relation between the new madness care and intervention service which is the Center for Psychosocial Care (CAPS), and the psychiatric view that was built throughout the XIX century. The CAPS that is supported by the precepts of the Brazilian Psychiatric Reform, purpose to combat the asylum assistance for madness model that last long over the centuries, especially supported by the modern period through the psychiatric discourse that look the madness as the object of its knowledge, transforming it into mental illness. The method of research was participant observation which passed through the direct presence oh the researcher on the study field, describing the elements that define the research object, such as: therapeutic workshops, group and family psychology, hospitality, collective or individual meetings and other activities which are part of the investigated service. It begins with a description of the object CAPS II: Santa Izabel, since its inception in Santa Izabel of Pará, in 2001 to its current settings. Then, the underlying precepts of the Psychiatric Reform ideologically governing this service, placing historical references leading to this reform movement, from Foucault‟s theoretical contributions on the transformation of psychiatric power and madness in disease, as well as other authors who seized of this issue within the Europe, Brazil and Pará were referenced. Psychoanalysis is taken in this dissertation as an opportunity to bet on a possible subject tha can succeed and exist, highlighting the Freud and Lacan‟s contributions about psychoanalytic theory of psychosis. Ends with data collected analysis, joined with bibliographic references, demonstrating that despite the CAPS propose a break with the asylum model established by psychiatric knowledge throughout that century, several actions that are supported on that objective update asylum practices that instead of giving a new place to madness, reissuing the imposed confinement on individuals who experienced this subjective experience. It concludes that the CAPS needs to make problematic and relative the regulated requirements by the Reformation and its law, to guarantee against the medicalization knowledge that is as present as before, and then get reinvent practices, concepts and ways of madness.
Acesso aberto (Open Access)
Trabalho precarizado e transtorno mental: a visão dos profissionais de um CAPS de Belém-PA
(Universidade Federal do Pará, 2015-12-14) NASCIMENTO, Rodolfo Valentim Carvalho do; MATHIS, Adriana de Azevedo; http://lattes.cnpq.br/4097998262711403
This study is the result of empirical research in the form of analysis of verbal reports of ten professionals of a CAPS Belém do Pará, in order to analyze the vision that have the relationship work and mental disorder, more specifically on the impact of changes the world of work in mental health workers who make treatment in CAPS and referring to their mental disorders as a result of poor working conditions and life. An outcome of this first objective the research sought to examine whether the institutional responses would meet the demands of users or restrict the medicalization/administration of their status as "mentally ill". As theoretical and methodological framework adopted the Marxist approach, which allowed a historical and theoretical review critical of mediations involving the relationship objectivity-subjectivity, in particular, the economic and social determinations present in contemporary capitalist sociability marked by job insecurity, increase social inequalities and trivialization of human from the obtaining of surplus value. The approach in mental health work and Seligmann-Silva and Dejours were also of paramount importance to an analysis of the widest possible data collected, in particular, studies of the harmful effects of the work process in the worker's subjectivity. The initial hypothesis of the research, which was confirmed, was that the changes in the working world, from the contemporary capitalist crisis, intensified the pace and working hours, precarious labor relations and consequently all dimensions of social life favoring the emergence of mental disorders and that such a phenomenon would be noticeable by the CAPS professionals. The elements of the world of work that impacted the mental health were: a lack of identification with work, competitive interpersonal relationships, poor facilities, stepping up the pace and working hours, lack of free time and social vulnerability. The survey also revealed that the deleterious effects of the new organization of work on mental health have shown extended to service professionals themselves, whose central element is the extension of the working day. Data on institutional responses show a tension between the actions favoring greater autonomy for users and actions focused on the administration \ medicalization of their status as "mentally ill", but with the hegemony of the first.