Dissertações em Odontologia (Mestrado) - PPGO/ICS
URI Permanente para esta coleçãohttps://repositorio.ufpa.br/handle/2011/2348
O Mestrado Acadêmico iniciou-se em 2004 e pertence ao Programa de Pós-Graduação em Odontologia da Universidade Federal do Pará (PPGO-UFPA) do Instituto de Ciências da Saúde (ICS) da Universidade Federal do Pará (UFPA).
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Dissertação Acesso aberto (Open Access) As proteínas TKS-4 e TKS-5, formadoras de invadopódios, são expressas no ameloblastoma e tumor odontogênico cístico calcificante(Universidade Federal do Pará, 2015-02-09) HORTA, Moema Ferreira dos Reis; PINHEIRO, João de Jesus Viana; http://lattes.cnpq.br/1365260779826770Dissertação Acesso aberto (Open Access) Expressão de metalotioneína e sua influência no comportamento biológico in vitro do carcinoma mucoepidermoide(Universidade Federal do Pará, 2017-02-22) AQUIME, João Rafael Habib Souza; PINHEIRO, João de Jesus Viana; http://lattes.cnpq.br/1365260779826770The Mucoepidermoid Carcinoma (MEC) is the most common tumor of salivary glands, presenting considerable rates of recurrence and distant metastasis due to high invasive capacity of tumor cells, probably favored by metallothionein (MT) actuation, an zinc storage protein that supply this element to protease activity and synthesis of proteins and nucleic acids. So, the aim of this paper was to characterize a cell line from MEC and to correlate expression of MT with the Transforming Growth Factor-α (TGF-α), Tumor Necrosis Factor-α (TNF-α) and Matrix Metalloproteinases (MMPs). Indirect Immunofluorescence assay was realized to detect expression to epithelial and mesenchymal markers. Besides, it was realized cytogenetic analysis to verify cellular chromosomal alterations. The metallothionein2A (MT2A) gene silencing was obtained by small-interference RNA (siRNA) assay, and then, western blot technique was performed to correlate the expression of growth factors and MMPs studied with MT-2A silencing. Indirect immunofluorescence revealed expression to cytokeratines 19 and AE1/AE3, fibronectin, vimentin andα-smooth muscle actin. Cytogenetic evaluation demonstrated several structural and numerical alterations, among which the translocation t(11;19) (q21;p13), characteristic of MEC. After siRNA assay, a decreased expression of TGF-α and MMP-9 was visualized, while TNF-α became more expressed and MMP-2 kept its expression unaltered. Our findings suggest that MT presents important role in tumor invasion mechanism in MEC, because it interferes with expression of proteins directly involved in this process.Dissertação Acesso aberto (Open Access) Análise clínica da doença periodontal em pacientes diabéticos tipo 2 correlacionada com o nível de hemoglobina glicada e proteína C-reativa(Universidade Federal do Pará, 2006-05) COSTA, Maria Elizabeth Gemaque; FELÍCIO, João Soares; http://lattes.cnpq.br/8482132737976863; CORRÊA, Adriano Maia; http://lattes.cnpq.br/6062379402457289Diabetes Mellitus is an endocrine disease that causes a large number of systemic disorders. It has been considered that diabetes may influence the installation and advancing of inflammatory periodontal disease, as seen with the wound healing difficulty, but is also influenced by periodontal disease, since the clinic course of periodontal disease may affect the glucose metabolism and diabetic control. So, the interrelationship between diabetes and periodontal disease has troubled the dental professionals. The aim of this study was to evaluate the clinical condition of periodontium in diabetic individuals type 2 and the necessity of periodontal treatment through Periodontal Screening Records (PSR), in conjunction with laboratorial analysis (HbA1c and high-sensitivity C-reactive protein-CRP). Of the 88 participants of the study, 5,69% had been presented free of disease; 36,36% had been presented with gingivitis and 57,95% had been presented with periodontitis. In the group of the not diabetic individuals, 51.06% had periodontitis, while 65.85% of the diabetic had presented the disease. The periodontal disease was presented more serious in the age group of 60-69 years (group not diabetic) and 70-79 years (group diabetic). All the diabetic had presented periodontal disease, and the score 3 (50,34%) was most prevalent In the group of the not diabetic individuals 89,36% had presented periodontal disease, and the score 2 (31,25%) was most prevalent.Although the high levels of C-reactive protein and the glycosylated hemoglobin, it did not have association with the gravity of the periodontal disease in the participants of the study.Dissertação Acesso aberto (Open Access) Avaliação do nível de conhecimento do uso de protocolos de urgência e/ou emergência médica na clínica odontológica(Universidade Federal do Pará, 2006-05-03) SILVA, Eliana Lago; NOGUEIRA, Antônio José da Silva; http://lattes.cnpq.br/5783562092456604It evaluates the students´ knowledge level in use of medical emergency and urgency protocols in assinaleted by Dentistry of , in 2005, in the city of Belém-PARÁ, regarding situations that can happen in pediatric and general dentistry service, as well as to describe their clinical aspects. Specific methodology was adopted with accomplishment of bibliographical research and questionnaire application with open and closed subjects, distributed to 121 students. It was verified that, although conscious about risks of these situations, most of them doesn't possess systematized knowledge about the necessary procedures in urgency and emergency cases and many them demonstrated interest in participating in an updating course about this subject. It was concluded that, most of the professionals doesn't have protocols of medical emergency and urgency, whose existence is fundamental to offer a secure service for all patients.