Alterações no comportamento motor e na bioquímica oxidativa de ratas intoxicadas agudamente com etanol no período inicial da adolescência

Abstract

Ethanol (EtOH) is one of the most commonly psychoactive substances consumed by young people, usually occurring in episodes of binge consumption, which is an intense form of drinking followed by a period of abstinence. In Brazil, the rates of alcohol abuse by female adolescents have increased in the past few years. This population is more sensitive to the neurotoxic effects of this substance since the complete development of structures such as the cerebellum occurs in this stage of life. Acute and chronic consumption of ethanol and its catabolism are associated with motor behavior alterations so as the generation of reactive oxygen species (ROS) and other metabolites. The purpose of this study was to investigate the effects of EtOH exposure following an acute binge pattern in female rats on their early adolescence (n = 20, n = 10 animals per group) received distilled water or EtOH (3 g / kg / day, 20 w / v) by gavage, for 3 consecutive days. Seven and a half hours after the last day of administration, the behavioral tests of spontaneous locomotor activity and rotarod were performed. Subsequently, the animals were sacrificed for cerebellum removal and the oxidative biochemical tests in cerebellar tissue were carried out. Behavioral tests showed that acute binge in rats on early adolescence did not alter spontaneous locomotor activity, but elicited alterations in motor learning. Oxidative biochemical results showed a high activity of catalase, which demonstrates that there was an offset of the body to reverse the ROS production in the cerebellum of adolescent rats acutely exposed to EtOH followed by a withdrawal period (binge).