Methylmercury inhibits prolactin release in a cell line of pituitary origin

dc.citation.issue8pt_BR
dc.citation.spage691pt_BR
dc.citation.volume48pt_BR
dc.creatorMAUÉS, Luis Antônio Loureiro
dc.creatorMACCHI, Barbarella de Matos
dc.creatorCRESPO LÓPEZ, Maria Elena
dc.creatorNASCIUTTI, Luís Eurico
dc.creatorDINIZ, Domingos Luiz Wanderley Picanço
dc.creator.Latteshttp://lattes.cnpq.br/4851018582496177pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/5330351659478942pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9900144256348265pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/8341603979365998pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9601463988942971pt_BR
dc.date.accessioned2017-05-17T16:37:47Z
dc.date.available2017-05-17T16:37:47Z
dc.date.issued2015-08
dc.description.abstractHeavy metals, such as methylmercury, are key environmental pollutants that easily reach human beings by bioaccumulation through the food chain. Several reports have demonstrated that endocrine organs, and especially the pituitary gland, are potential targets for mercury accumulation; however, the effects on the regulation of hormonal release are unclear. It has been suggested that serum prolactin could represent a biomarker of heavy metal exposure. The aim of this study was to evaluate the effect of methylmercury on prolactin release and the role of the nitrergic system using prolactin secretory cells (the mammosomatotroph cell line, GH3B6). Exposure to methylmercury (0-100 μM) was cytotoxic in a time- and concentration-dependent manner, with an LC50 higher than described for cells of neuronal origin, suggesting GH3B6 cells have a relative resistance. Methylmercury (at exposures as low as 1 μM for 2 h) also decreased prolactin release. Interestingly, inhibition of nitric oxide synthase by N-nitro-L-arginine completely prevented the decrease in prolactin release without acute neurotoxic effects of methylmercury. These data indicate that the decrease in prolactin production occurs via activation of the nitrergic system and is an early effect of methylmercury in cells of pituitary origin.pt_BR
dc.description.affiliationMAUÉS, L. A. L. Dr. Docente da Universidade Federal do Pará, Campus Universitário de Altamirapt_BR
dc.description.affiliationMACCHI, B. de M. Dr. Docente da Universidade Federal do Pará, Instituto de Ciências Biológicaspt_BR
dc.description.affiliationCRESPO LÓPEZ, M. E. Dr. Docente da Universidade Federal do Pará, Insituto de Ciências Biológicaspt_BR
dc.identifier.citationMAUES, Luís Antônio Loureiro et al. Methylmercury inhibits prolactin release in a cell line of pituitary origin. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 48, n. 8, p. 691-696, ago. 2015. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/8442>. Acesso em:.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/1414-431X20154165pt_BR
dc.identifier.issn1414-431Xpt_BR
dc.identifier.urihttps://repositorio.ufpa.br/handle/2011/8442
dc.languageporpt_BR
dc.publisherUniversidade Federal do Parápt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFPApt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.source.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800691&lng=pt&nrm=isopt_BR
dc.subjectMetilmercúriopt_BR
dc.subjectProlactinapt_BR
dc.subjectMetais pesadospt_BR
dc.subjectCélulas secretoraspt_BR
dc.subjectPituitáriapt_BR
dc.subjectMercúriopt_BR
dc.titleMethylmercury inhibits prolactin release in a cell line of pituitary originpt_BR
dc.typeArtigo de Periódicopt_BR
dcterms.citation.epage696pt_BR

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