Avaliar a influência do tratamento crônico com vitamina C em um modelo de estresse provocado pela dor inflamatória induzida por ácido acético em ratos wistar adolescentes

Abstract

Stress in adolescence may be linked to consequences that may persist throughout life. The injuries suffered in the brain, due to exposure to stress factors, contribute to the development of pathologies related to behavior and emotionality, such as anxiety and depression. These two pathologies have been taking on increasingly frightening proportions these days, especially among adolescents and young people, due to brain plasticity in this phase. Therefore, the aim of this study was to evaluate the influence of chronic vitamin C treatment on stress in adolescent animals in a model of inflammatory pain induced by acetic acid. Using the open field test, vitamin C was shown to significantly reduce anxiety-related behavior. This chronic treatment also satisfactorily reversed memory and learning deficits in Morris water maze. In conclusion, the chronic treatment with vitamin C has beneficial effects on the emotionality and behaviors of adolescent animals submitted to acetic acid injections. In addition, the acetic acid injection model has been shown to be efficient in inducing an anxious state of the animals.