Intercalação de ácido caféico em hidróxido duplo lamelar pelo método de troca iônica: novas formulações leshimanicida

Abstract

The drug delivery systems shows several advantages when compared with traditional release systems, such as allowing the employment of lower concentrations of drug, having greater efficiency, and minimizing side effects. The improvement of drug delivery depends strictly on the choice of and adequate support allowing to effectively controlling the drug release. Thus, the use of inorganic hybrid materials, such as layered doubles hydroxides (LDH) is of great interest because of their properties. Caffeic acid (CA), coming from several natural sources, exhibits different biological activities with featured for the leishmanicidal activity. In this work, the ion exchange methodology was used for the intercalation of Caffeic acid (CA) molecules between the LDH/MgAl layers. This, in order to obtain more stable AC formulations compared to free drug. Physico-chemical characterizations were used for analysis of the structure and morphology of the hybrid compounds obtained, such as XRD, FT-IR and SEM.