O uso de compostos fenólicos na prevenção da doença de parkinson: análise bibliométrica e crítica dos 100 artigos mais citados da Web of Science e avaliação neuroprotetora do açaí (euterpe oleracea) em ratos wistar

Abstract

Parkinson's disease is characterized by the death of dopaminergic neurons with both motor and non-motor symptoms. The current treatment available does not prevent the progression of the disease and, therefore, new alternatives have been sought for its prevention. Phenolic compounds that are present in foods and beverages of plant origin have bioactivities including antioxidant and anti-inflammatory activity that may contribute to neuroprotection. The general objective of this thesis is to evaluate bibliometric parameters and experimental designs of the 100 most cited articles from WoS-CC on the use of phenolic compounds in Parkinson's disease and to carry out an in vivo laboratory study using Wistar rats exposed to açaí for 15 days before induction of Parkinson's disease-like symptoms through 6-hydroxydopamine. The 100 most cited articles in WoS-CC are predominantly from the Asian continent and China, EGCG and oxidative stress being the most evaluated compound and therapeutic target among the 100 studies. In vitro and in vivo laboratory studies represent approximately 70% of the list. The results demonstrated among the 100 articles are due to concentrations and administration routes that do not resemble consumption through the diet. Pre-treatment with açaí increased GSH levels and decreased MDA levels, in addition to preventing damage to spontaneous locomotion. The results suggest the neuroprotective potential of açaí related to its composition of phenolic compounds.