Use este identificador para citar ou linkar para este item:
https://repositorio.ufpa.br/jspui/handle/2011/2422
Tipo: | Artigo de Periódico |
Data do documento: | Jun-2010 |
Autor(es): | VIEIRA, José Luiz Fernandes RIVERA, Juan Gonzalo Bardález MARTINS, Ana de Nazaré Silva SILVA, Jorge Pereira da SALGADO, Claudio Guedes |
Título: | Methemoglobinemia and dapsone levels in patients with leprosy |
Citar como: | VIEIRA, Jose Luiz Fernandes et al. Methemoglobinemia and dapsone levels in patients with leprosy. Brazilian Journal of Infectious Diseases, Salvador, v. 14, n. 3, p.319-321, maio/jun. 2010. Disponível em: <http://www.scielo.br/pdf/bjid/v14n3/v14n3a22.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S1413-86702010000300022. |
Abstract: | The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia. |
Palavras-chave: | Metemoglobina Dapsona Hanseníase Doenças infecciosas |
ISSN: | 1413-8670 |
Tipo de Acesso: | Acesso Aberto |
Aparece nas coleções: | Artigos Científicos - FARM/ICS |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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Artigo_MethemoglobinemiaDapsoneLevels.pdf | 687,86 kB | Adobe PDF | Visualizar/Abrir |
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