Correlação entre as concentrações sérica e eritrocitária de quinina no estado de equilíbrio em pacientes com malária por Plasmodium falciparum não complicada

Abstract

The correlation between the serum and red blood cells concentrations of quinine was studied in children and adults with falciparum malaria uncomplicated in Cachoeira of the Piriá, in the State of Pará. The patients had received the oral scheme of quinine (3 days) + doxycyclina (5 days) + primaquine (6º day). Quinine concentration in the serum and the red blood cells samples was measured by High Performance Liquid Chromatography in the third day of treatment. The average of the serum concentration of the quinine in children with uncomplicated falciparum malaria was of 0,723 ± 0,6 μg/mL, and 0,537 ± 0,38 μg/mL for the red blood cells. And the relationship between the serum and red blood cells concentration was 1,89 ± 1,25 μg/mL, had not difference statistical significant between those concentrations. The average of the serum concentration of adult individuals was of 1,27 ± 1,12 μg/mL, and 0,63 ± 0,48 μg/mL for the red blood cells. The relationship between those concentration was of 2,27 ± 1,06 μg/mL. The results had shown that it did not have significant statistical difference between the averages of the relation of quinine levels in the serum and the red blood cells of the children and the adults.