Detecção molecular do Papilomavirus humano (HPV) em amostras teciduais de tumores da mama

Abstract

The malignant neoplasm of breast is a major cause of female mortality, considered as a public health problem. In this work researched the presence of human papillomavirus (HPV) in benign and malignant breast tumors and normal breast tissue samples. Was used the technique of Polymerase chain reaction (PCR) for HPV DNA molecular detection in 63 patients, thus distributed: 28 malignant and 17 benign tumors and 18 are samples of normal breast. Our results showed positivity for HPV DNA sequence in 11 samples, all belonging to the bearers of malignant tumors: 17.4% of all samples and 39.2% of malignant tumors. All positive HPV DNA showed tumors for oncogênicos types 16 and/or 18, was not detected HPV 6 and 11 DNA. The results demonstrated high positivity to the hormonal receptors in positive samples examined and presented a follow-up with prevalence of adverse events as relapse loco-regional metastases and death in with HPV DNA. Finds ratify the data found in the literature, showing a possible participation of this virus in the development of breast cancer and possible unfavorable contribution in clinical evolution.