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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2012
metadata.dc.creator: SANTOS, Daniel Valle Vasconcelos
COSTA, Kauê Machado
SILVA FILHO, Manoel da
VAZ, Manoella Cristina Gadelha
Title: Relationships between dendritic morphology, spatial distribution and firing patterns in rat layer 1 neurons
Citation: SANTOS, D.V.V. et al. Relationships between dendritic morphology, spatial distribution and firing patterns in rat layer 1 neurons. Brazilian Journal of Medical and Biological Research, v. 45, n. 12, p. 1221-1233, dez. 2012. Disponível em: <>. Acesso em: 20 fev. 2014.
Abstract: The cortical layer 1 contains mainly small interneurons, which have traditionally been classified according to their axonal morphology. The dendritic morphology of these cells, however, has received little attention and remains ill defined. Very little is known about how the dendritic morphology and spatial distribution of these cells may relate to functional neuronal properties. We used biocytin labeling and whole cell patch clamp recordings, associated with digital reconstruction and quantitative morphological analysis, to assess correlations between dendritic morphology, spatial distribution and membrane properties of rat layer 1 neurons. A total of 106 cells were recorded, labeled and subjected to morphological analysis. Based on the quantitative patterns of their dendritic arbor, cells were divided into four major morphotypes: horizontal, radial, ascendant, and descendant cells. Descendant cells exhibited a highly distinct spatial distribution in relation to other morphotypes, suggesting that they may have a distinct function in these cortical circuits. A significant difference was also found in the distribution of firing patterns between each morphotype and between the neuronal populations of each sublayer. Passive membrane properties were, however, statistically homogeneous among all subgroups. We speculate that the differences observed in active membrane properties might be related to differences in the synaptic input of specific types of afferent fibers and to differences in the computational roles of each morphotype in layer 1 circuits. Our findings provide new insights into dendritic morphology and neuronal spatial distribution in layer 1 circuits, indicating that variations in these properties may be correlated with distinct physiological functions.
Keywords: Biocitina
Morfologia dentrítica
Camada Cortical 1
Variabilidade neuronal
ISSN: 0100-879X
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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