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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2013
metadata.dc.creator: BRITO, Marcus Vinicius Henriques
YASOJIMA, Edson Yuzur
SILVEIRA, Edvaldo Lima
YAMAKI, Vitor Nagai
TEIXEIRA, Renan Kleber Costa
FEIJÓ, Daniel Haber
GONÇALVES, Thiago Barbosa
metadata.dc.description.affiliation: YASOJIMA, E. Y.; SILVEIRA, E. L. Universidade Federal do Pará
Title: New experimental model of exposure to environmental tobacco smoke
Citation: BRITO, Marcus Vinicius Henriques et al. New experimental model of exposure to environmental tobacco smoke. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 12, p. 815-819, Dec. 2013. DOI: Disponível em: Acesso em:.
Abstract: PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS: There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION: The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.
Keywords: Pneumopatias
Lesão por inalação de fumaça
Rato como animal de laboratório
Lung diseases
Smoke inhalation injury
Series/Report no.: Acta Cirúrgica Brasileira
ISSN: 1678-2674 Brasil
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
metadata.dc.publisher.initials: SOBRADPEC
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FAMED/ICS

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