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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2016
metadata.dc.creator: PITITTO, Bianca de Almeida
RIBEIRO FILHO, Fernando de Souza Flexa
BARRETO, Sandhi Maria
DUNCAN, Bruce Bartholow
SCHMIDT, Maria Inês
LOTUFO, Paulo Andrade
BENSENOR, Isabela Judith Martins
VIVOLO, Sandra Roberta Gouvea Ferreira
Title: Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease
Citation: PITITTO, Bianca de Almeida et al. Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 6, p. 573-581, nov./dez. 2016. Disponível em: <>. Acesso em: 15 mar. 2017. Epub 05-Set-2016. <>.
Abstract: Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This crosssectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results: Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions: In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
Keywords: Biomarcadores
Saúde coletiva
Series/Report no.: Archives of Endocrinology and Metabolism
ISSN: 2359-4292 Brasil
Publisher: Universidade Federal do Pará
metadata.dc.publisher.initials: UFPA
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICS

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