Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.creatorPITITTO, Bianca de Almeida-
dc.creatorRIBEIRO FILHO, Fernando de Souza Flexa-
dc.creatorBARRETO, Sandhi Maria-
dc.creatorDUNCAN, Bruce Bartholow-
dc.creatorSCHMIDT, Maria Inês-
dc.creatorLOTUFO, Paulo Andrade-
dc.creatorBENSENOR, Isabela Judith Martins-
dc.creatorVIVOLO, Sandra Roberta Gouvea Ferreira-
dc.identifier.citationPITITTO, Bianca de Almeida et al. Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 6, p. 573-581, nov./dez. 2016. Disponível em: <>. Acesso em: 15 mar. 2017. Epub 05-Set-2016. <>.pt_BR
dc.description.abstractOur aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This crosssectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results: Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions: In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.pt_BR
dc.publisherUniversidade Federal do Parápt_BR
dc.relation.ispartofArchives of Endocrinology and Metabolismpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSaúde coletivapt_BR
dc.titleCirculating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular diseasept_BR
dc.typeArtigo de Periódicopt_BR
Appears in Collections:Artigos Científicos - ICS

Files in This Item:
File Description SizeFormat 
Artigo_CirculatingEarlyBiomarkers.pdf191,23 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.