Estudo de potenciais marcadores moleculares de suscetibilidade ao câncer de pulmão

Abstract

Lung cancer is a major public health problem, currently occupying the tenth position among the leading causes of death worldwide and the leading cause of death among cancer. The individual predisposition to developing lung cancer could be associated with genetic polymorphisms related to the inflammatory response, activation mechanisms and detoxification or carcinogens, as well as defects in the mechanisms of the DNA repair. This study aimed to investigate the influence of 13 polymorphisms of the type insertion / deletion in genes of the metabolism and biotransformation (CYP2E1, CYP19A1 and UGT1A1), control genes of the immune system and inflammatory response (IL1A and IL4), genes that regulate control of gene function of the cell cycle and immune system (MDM2 and NFKB1), DNA repair genes (TYMS and XRCC1), regulator of apoptosis gene (CASP 8), regulator of hemostasis gene (PAR1) and control gene cell cycle (TP53) as susceptibility to lung cancer. Polymorphisms were genotyped by a multiplex PCR reaction of patients with a confirmed diagnosis for lung cancer and individuals from the same population without the disease. The genetic ancestry of all individuals were estimated by a panel of ancestry informative markers. A logistic regression analysis controlling for age, gender and smoking was performed to determine the influence of polymorphisms in susceptibility to cancer. No statistically significant differences between the groups with cancer and without cancer were founded. Polymorphisms studied are not associated with susceptibility to lung cancer in the Pará population.