Use este identificador para citar ou linkar para este item: https://repositorio.ufpa.br/jspui/handle/2011/9588
Tipo: Artigo de Periódico
Data do documento: Out-2014
Autor(es): SOUZA, Ana Maria Almeida
MUNIZ, Thiago Pimentel
BRITO, Rafael Maciel
Título: Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment
Citar como: SOUZA, Ana Maria Almeida; MUNIZ, Thiago Pimentel; BRITO, Rafael Maciel. Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment. Revista Brasileira de Hematologia e Hemoterapia, São José do Rio Preto, v. 36, n. 5, p. 345-350, out. 2014. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/9588>. Acesso em:
Abstract: Objective: to evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment. Methods: data were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test. Results: there was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy. Conclusions: there are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature.
Palavras-chave: Doença de Gaucher
Esplenomegalia
Anemia
Terapia de substituição enzimática
CNPq: CNPQ::CIENCIAS DA SAUDE
Título do Periódico: Revista Brasileira de Hematologia e Hemoterapia
ISSN: 1516-8484
País: Brasil
Instituição: Universidade Federal do Pará
Sigla da Instituição: UFPA
Tipo de Acesso: Acesso Aberto
Fonte URI: http://www.scielo.br/pdf/rbhh/v36n5/1516-8484-rbhh-36-05-0345.pdf
Identificador DOI: http://dx.doi.org/10.1016/j.bjhh.2014.05.005
Aparece nas coleções:Artigos Científicos - FAMED/ICS

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo_StudyEnzymeReplacement.pdf542,35 kBAdobe PDFVisualizar/Abrir


Este item está licenciado sob uma Licença Creative Commons Creative Commons