Use este identificador para citar ou linkar para este item:
https://repositorio.ufpa.br/jspui/handle/2011/9588
Tipo: | Artigo de Periódico |
Data do documento: | Out-2014 |
Autor(es): | SOUZA, Ana Maria Almeida MUNIZ, Thiago Pimentel BRITO, Rafael Maciel |
Título: | Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment |
Citar como: | SOUZA, Ana Maria Almeida; MUNIZ, Thiago Pimentel; BRITO, Rafael Maciel. Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment. Revista Brasileira de Hematologia e Hemoterapia, São José do Rio Preto, v. 36, n. 5, p. 345-350, out. 2014. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/9588>. Acesso em: |
Abstract: | Objective: to evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment. Methods: data were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test. Results: there was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy. Conclusions: there are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature. |
Palavras-chave: | Doença de Gaucher Esplenomegalia Anemia Terapia de substituição enzimática |
CNPq: | CNPQ::CIENCIAS DA SAUDE |
Título do Periódico: | Revista Brasileira de Hematologia e Hemoterapia |
ISSN: | 1516-8484 |
País: | Brasil |
Instituição: | Universidade Federal do Pará |
Sigla da Instituição: | UFPA |
Tipo de Acesso: | Acesso Aberto |
Fonte URI: | http://www.scielo.br/pdf/rbhh/v36n5/1516-8484-rbhh-36-05-0345.pdf |
Identificador DOI: | http://dx.doi.org/10.1016/j.bjhh.2014.05.005 |
Aparece nas coleções: | Artigos Científicos - FAMED/ICS |
Arquivos associados a este item:
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Artigo_StudyEnzymeReplacement.pdf | 542,35 kB | Adobe PDF | Visualizar/Abrir |
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