Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/10874
metadata.dc.type: Artigo de Periódico
Issue Date: 2-Jun-2015
metadata.dc.creator: ALMEIDA, Izabela Negrão Frota de
ALMEIDA, Luciana Negrão Frota de
SOBRINHO, Edmundo Frota de Almeida
GOMES, Bruno Duarte
SOUZA, Givago da Silva
ROSA, Alexandre Antonio Marques
SILVEIRA, Luiz Carlos Lima
metadata.dc.description.affiliation: GOMES, Bruno Duarte. Universidade Federal do Pará, Instituto de Ciências Biológicas (ICB)
Title: Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
Other Titles: Tomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabe
Citation: ALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.
Abstract: To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.
Keywords: Macular degeneration/drug therapy
Antibodies
Tomography optical coherence
Electroretinography
Intravitreal injections
Series/Report no.: Arquivos Brasileiros de Oftalmologia
ISSN: 0004-2749
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal do Pará
metadata.dc.publisher.initials: UFPA
metadata.dc.rights: Acesso Aberto
metadata.dc.source.uri: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000200010&lng=pt&nrm=iso
metadata.dc.identifier.doi: http://dx.doi.org/10.5935/0004-2749.20150027
Appears in Collections:Artigos Científicos - ICB

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