Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/6121
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Type: Artigo de Periódico
Issue Date: Dec-2005
Authors: MARTINS, Luisa Caricio
CORVELO, Tereza Cristina de Oliveira
DEMACHKI, Samia
ARAÚJO, Marialva Tereza Ferreira de
ASSUMPÇÃO, Mônica Baraúna de
VILAR, Simone Cristina Araujo Jucá
FREITAS, Felipe Bonfim
BARBOSA, Hivana Patricia Melo
FECURY, Amanda Alves
AMARAL, Renata Kelly Costa do
SANTOS, Sidney Emanuel Batista dos
Title: Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil
Citation: MARTINS, Luisa Caricio et al. Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 8, p. 875-881, dez. 2005. Disponível em: <http://www.scielo.br/pdf/mioc/v100n8/v100n8a09.pdf>. Acesso em: 25 nov. 2014. <http://dx.doi.org/10.1590/S0074-02762005000800009>.
Abstract: We have examined the prevalence of gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological data. vacA and cagA genotype were determined by polymerase chain reaction. Hematoxylin-eosin staining was used for histological diagnosis. 96.6% of the patients were colonized by Helicobacter pylori strains harboring single vacA genotype (nont-mixed infection). Among them, 11.8% had subtype s1a, 67.8% had subtype s1b, and 17% subtype s2. In regard to the middle region analysis, m1 alleles were found in 75.4% and m2 in 21.2% of patients. The cagA gene was detected in 78% patients infected with H. pylori and was associated with the s1-m1 vacA genotype. The H. pylori strains, vacA s1b m1/cagA-positive, were associated with increased risk of peptic ulcer disease and higher amounts of lymphocytic and neutrophilic infiltrates and the presence of intestinal metaplasia. These findings show that cagA and vacA genotyping may have clinical relevance in Brazil.
Keywords: Helicobacter pylori
Prevalência
Úlcera péptica
Alelos vacA
Estatos cagA
Brasil - País
ISSN: 0074-0276
Appears in Collections:Artigos Científicos - ICB

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