Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/6335
metadata.dc.type: Artigo de Periódico
Issue Date: Aug-2014
metadata.dc.creator: BOTELHO, Nara Macedo
SILVEIRA, Edvaldo Lima
LOPES, Letícia Nobre
SANTOS, Felipe Augusto Folha
TEIXEIRA, Renan Kleber Costa
SILVA, Thaís Travassos da
metadata.dc.description.affiliation: SILVEIRA, E. L. Universidade Federal do Pará
Title: Copaiba oil effect under different pathways in mice subjected to sepsis
metadata.dc.description.sponsorship: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
Citation: BOTELHO, Nara Macedo et al. Copaiba oil effect under different pathways in mice subjected to sepsis. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 528-531, Aug. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000800008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6335. Acesso em:.
Abstract: PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
Keywords: Plantas medicinais
Óleo de copaíba
Doenças peritoneais
Rato como animal de laboratório
Balsams
Peritoneal diseases
Ligation
Mice
Series/Report no.: Acta Cirúrgica Brasileira
ISSN: 1678-2674
metadata.dc.publisher.country: Brasil
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
metadata.dc.publisher.initials: SOBRADPEC
metadata.dc.rights: Acesso Aberto
metadata.dc.source.uri: http://ref.scielo.org/fdkky3
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0102-86502014000800008
Appears in Collections:Artigos Científicos - ICB

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