Please use this identifier to cite or link to this item: http://repositorio.ufpa.br/jspui/handle/2011/6337
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Type: Artigo de Periódico
Issue Date: Dec-2013
Authors: BRITO, Marcus Vinicius Henriques
YASOJIMA, Edson Yuzur
SILVEIRA, Edvaldo Lima
YAMAKI, Vitor Nagai
TEIXEIRA, Renan Kleber Costa
FEIJÓ, Daniel Haber
GONÇALVES, Thiago Barbosa
Title: New experimental model of exposure to environmental tobacco smoke
Citation: BRITO, Marcus Vinicius Henriques et al. New experimental model of exposure to environmental tobacco smoke. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 12, p. 815-819, dez. 2013. Disponível em: <http://www.scielo.br/pdf/acb/v28n12/v28n12a02.pdf>. Acesso em: 23 fev. 2015. <http://dx.doi.org/10.1590/S0102-86502013001200002>.
Abstract: PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS: There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION: The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.
Keywords: Pneumopatias
Lesão por inalação de fumaça
Rato como animal de laboratório
ISSN: 1678-2674
Appears in Collections:Artigos Científicos - FAMED/ICS

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