Faculdade de Medicina - FAMED/ICS
URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/2424
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Item Acesso aberto (Open Access) Analysis of imatinib adherence in chronic myeloid leukemia: a retrospective study in a referral hospital in the brazilian amazon(Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular, 2019-06) ANDRADE, Alan Rodrigues; PAZ, Igor Penha; EVANGELISTA, Talitta Ribeiro; MELLO, Vanessa Joia de; HAMOY, Moisés; LEITÃO, Daniel da SilvaBackground: There has been a revolution in the treatment of Chronic Myeloid Leukemia since imatinib's introduction. However, patient adherence has a great impact on the response obtained with medical treatment. This study's objective was to analyze the drug adherence and the factors that influenced it in patients with Chronic Myeloid Leukemia in a referral hospital in the Brazilian Amazon. Method: This was a retrospective study including 120 patients with Chronic Myeloid Leukemia from January 2002 to December 2014. The adherence was estimated by the Proportion of Days Covered and the persistence by Kaplan-Meier analysis. The data was analyzed in Epi Info 7® software and the relationship between the variables was analyzed by Fisher's exact test. A p-value lower than 0.05 was considered significant. Results: Twenty-seven patients (22.5%) were considered non-adherent. There has been irregular medication use and disinterest in the treatment in 20.83% (n = 25), of which 13 were considered non-adherent (p < 0.001). A total of 26.67% (n = 32) abandoned the treatment for a period. Of those, 56.25% (n = 18) were non-adherent (p < 0.001). Distance to the hospital, lack of medication and side-effects were all non-significant to low adherence. At the end of a 360-day follow-up, 44.16% (n = 53) of patients presented a break in persistence, whose average was 255 days. Conclusion: The adherence found in this study was similar to that found in others of its kind. The only factors that negatively influenced the adherence were disinterest and abandonment of treatment, which can reflect the need to individually educate Chronic Myeloid Leukemia patients.Item Acesso aberto (Open Access) Principais queixas vocais de pacientes idosos pós-tratamento para hanseníase(Sociedade Brasileira de Geologia, 2010-04) PALHETA NETO, Francisco Xavier; SILVA FILHO, Manoel da; PANTOJA JUNIOR, José Mariano Soriano; TEIXEIRA, Larissa Lane Cardoso; MIRANDA, Rafaela Vale de; PALHETA, Angélica Cristina PezzinLeprosy is an infectious disease, with vocal involvement varying between hoarseness and difficult breathing. Aim: compare the main vocal complaints among elderly patients after treatment for leprosy and a control group. Study design: descriptive prospective. Materials and methods: We included 50 patients aged over 60 years, 32 had been treated for leprosy, and the others formed the control group. We used our own questionnaire to analyze the vocal symptoms presented by the two groups, as well as gender, age, life style and comorbidities. Results: among the treated group, the most frequent symptoms were hawk (34.4%) and hoarseness (28.1%), while in the control group the most prevalent symptoms were hoarseness (77.8%) and a foreign body sensation (55.6%). Conclusion: the most prevalent voice complaints in patients treated for leprosy are hawking and hoarseness, and that its development is influenced by life style and associated diseases.