Faculdade de Medicina - FAMED/ICS

URI Permanente desta comunidadehttps://repositorio.ufpa.br/handle/2011/2424

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Navegando Faculdade de Medicina - FAMED/ICS por Periódicos "Revista Brasileira de Reumatologia"

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    Artrite enteropática no Brasil: dados do registro brasileiro de espondiloartrites
    (Universidade Federal do Pará, 2013-12) RESENDE, Gustavo Gomes; LANNA, Cristina Costa Duarte; BERTOLUZZO, Adriana Bruscato; GONÇALVES, Celio Roberto; XIMENES, Antonio Carlos; BERTOLO, Manoel Barros; KEISERMAN, Mauro Waldemar; MENIN, Rita de Cássia; SKARE, Thelma Larocca; CARNEIRO, Sueli Coelho da Silva; AZEVEDO, Valderílio Feijó; VIEIRA, Walber Pinto; BIANCHI, Washington Alves; BONFIGLIOLI, Rubens; CAMPANHOLO, Cristiano Barbosa; CARVALHO, Hellen Mary da Silveira de; COSTA, Izaias Pereira da; DUARTE, Angela Luzia Branco Pinto; KOHEM, Charles Lubianca; MEIRELLES, Eduardo de Souza; PEREIRA, Ivânio Alves; PINHEIRO, Marcelo de Medeiros; POLITO, Elizandra Tomazela Laurenti; ROCHA, Francisco Airton Castro da; SANTIAGO, Mittermayer Barreto; CUNHA, Maria de Fátima Lobato da; VALIM, Valéria; BARROS, Percival Degrava Sampaio; RIBEIRO, Sandra Lúcia Euzébio; SILVA, José Antonio Braga da; ALBUQUERQUE, Elisa N.; LEITE, Nocy; LIMA, Sonia A. L.
    Inflammatory bowel diseases (Crohn’s disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis. Methods: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Laboratory and radiographic examinations were performed. The aim of this study is to compare the clinical, epidemiological, genetic, imaging, treatment and prognosis characteristics of patients with enteropathic arthritis with other types of spondyloarthritis in a large Brazilian cohort. Results: A total of 3.2% of patients were classified as having enteroarthritis, 2.5% had spondylitis and 0.7%, arthritis (peripheral predominance). The subgroup of individuals with enteroarthritis had a higher prevalence in women (P < 0.001), lower incidence of inflammatory axial pain (P < 0.001) and enthesitis (P = 0.004). HLA-B27 was less frequent in the group with enteroarthritis (P = 0.001), even when considering only those with the pure axial form. There was a lower prevalence of radiographic sacroiliitis (P = 0.009) and lower radiographic score (BASRI) (P = 0.006) when compared to patients with other types of spondyloarthritis. They also used more corticosteroids (P < 0.001) and sulfasalazine (P < 0.001) and less nonsteroidal anti-inflammatory drugs (P < 0.001) and methotrexate (P = 0.001). Conclusion: There were differences between patients with enteroarthritis and other types of spondyloarthritis, especially higher prevalence of females, lower frequency of HLA-B27, associated with less severe axial involvement.
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    Incidence of tuberculosis among patients with rheumatoid arthritis using TNF blockers in Brazil: data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas – BiobadaBrasil)
    (Universidade Federal do Pará, 2017) YONEKURA, Claudia Leiko Yonekura; OLIVEIRA, Renê Donizeti Ribeiro de; RANZA, Roberto; RANZOLIN, Aline; HAYATA, André Luiz Shinji; SILVEIRA, Inês Guimarães da; CARVALHO, Hellen Mary da Silveira de; MORAES, Julio Cesar Bertacini de; ABREU, Mirhelen Mendes de; VALIM, Valéria; BIANCHI, Washington Alves; BRENOL, Claiton Viegas; PEREIRA, Ivânio Alves; COSTA, Izaias Pereira da; MACIEIRA, José Caetano; GUEDES-BARBOSA, Luiz Sérgio; BERTOLO, Manoel Barros; CUNHA, Maria de Fátima Lobato da; SILVA, Marília Barreto Gameiro; FREIRE, Marlene; SCHEINBERG, Morton Aaron; TOLEDO, Roberto Acayaba de; OLIVEIRA, Sheila Knupp Feitosa de; FERNANDES, Vander; PINHEIRO, Marcelo de Medeiros; CASTRO, Gláucio Ricardo Werner de; VIEIRA, Walber Pinto; BAAKLINI, Cesar Emile; RUFFINO-NETTO, Antonio; PINHEIRO, Geraldo da Rocha Castelar; LAURINDO, Ieda Maria Magalhães; LOUZADA-JUNIOR, Paulo; TITTON, David C.; DUARTE, Angela; MIRANDA, Jose R. S.
    Objectives: To assess the incidence of tuberculosis and to screen for latent tuberculosis infection among Brazilians with rheumatoid arthritis using biologics in clinical practice. Patients and methods: This cohort study used data from the Brazilian Registry of Biological Therapies in Rheumatic Diseases (Registro Brasileiro de Monitoração de Terapias Biológicas - BiobadaBrasil), from 01/2009 to 05/2013, encompassing 1552 treatments, including 415 with only synthetic disease-modifying anti-rheumatic drugs, 942 synthetic DMARDs combined with anti-tumor necrosis factor (etanercept, infliximab, adalimumab) and 195 synthetic DMARDs combined with other biologics (abatacept, rituximab and tocilizumab). The occurrence of tuberculosis and the drug exposure time were assessed, and screening for tuberculosis was performed. Statistical analysis: Unpaired t-test and Fisher's two-tailed test; p < 0.05. Results: The exposure times were 981 patient-years in the controls, 1744 patient-years in the anti-TNF group (adalimumab = 676, infliximab = 547 and etanercept = 521 patient-years) and 336 patient-years in the other biologics group. The incidence rates of tuberculosis were 1.01/1000 patient-years in the controls and 2.87 patient-years among anti-TNF users (adalimumab = 4.43/1000 patient-years; etanercept = 1.92/1000 patient-years and infliximab = 1.82/1000 patient-years). No cases of tuberculosis occurred in the other biologics group. The mean drug exposure time until the occurrence of tuberculosis was 27(11) months for the anti-TNF group. Conclusions: The incidence of tuberculosis was higher among users of synthetic DMARDs and anti-TNF than among users of synthetic DMARDs and synthetic DMARDs and non-anti-TNF biologics and also occurred later, suggesting infection during treatment and no screening failure.
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