Investigação dos prejuízos motores decorrentes da exposição crônica ao etanol, em ratas intoxicadas da adolescência à fase adulta

Abstract

According to the World Health Organization, ethanol is the most widely used psychoactive drug in the world, occupying a prominent place by now be considered a public health problem worldwide. His heavy drinking among adolescents is on the rise, from 15 years and young adults A wide variety of research related to its damaging many organs and body systems effects, as well as damage and degeneration of the central nervous system structures, and the cerebellum one of its main targets is the affinity of the substance for cellular structures is the ability to generate a cascade of deleterious processes . The aim of this study was to evaluate behavioral changes associated with the cerebellum in rats chronically intoxicated with ethanol adolescence to adulthood. Female at 35 days of postnatal life received during 55 days, ethanol by gavage. After this period of intoxication, the animals underwent a battery of tests to assess motor deficits. Behavioral tests consisted Open Field, Pole Test, Walking Beam and Rotarod. The results showed that animals exposed to ethanol displayed motor deficits in all behavioral tests. Although several mechanisms are associated with cerebellar degeneration, further studies should be conducted to investigate the true effect of this drug and their correlation wiser the results obtained in this research.